ArticleOrganic letters2013
Synthesis of plantazolicin analogues enables dissection of ligand binding interactions of a highly selective methyltransferase.
Article in Organic letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- New developments in RiPP discovery, enzymology and engineering.Natural product reports · 2021Review
- YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function.Chemical reviews · 2017Review
- Plantazolicin is an ultra-narrow spectrum antibiotic that targets theACS infectious diseases · 2016Article
- Insights into methyltransferase specificity and bioactivity of derivatives of the antibiotic plantazolicin.ACS chemical biology · 2015Article
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Authors and funding
3 authors.
Funding
Abstract
A convergent strategy for the synthesis of truncated analogues of plantazolicin (PZN), a member of the thiazole/oxazole-modified microcin (TOMM) class of natural products, has been developed. These N-terminal mono-, tri-, and pentazole substructures of PZN were utilized to probe the substrate requirements and thermodynamic ligand binding parameters of an unusually selective PZN methyltransferase (BamL) by isothermal titration calorimetry. Our results demonstrate that the presence of a single N-terminal azole permits efficient processing by BamL; however, the substrate binding becomes stronger with increased polyazole chain length.
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