ArticleJournal of palliative medicine2013
Could triaging family history of cancer during palliative care enable earlier genetic counseling intervention?
Article in Journal of palliative medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- A survey of genetic and palliative care health professionals' views of integrating genetics into palliative care.European journal of human genetics : EJHG · 2024Article
- Approaching discussions about genetics with palliative patients and their families: a qualitative exploration with genetic health professionals.European journal of human genetics : EJHG · 2023Article
- Views and experiences of palliative care clinicians in addressing genetics with individuals and families: a qualitative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- The Role of Palliative Medicine in Assessing Hereditary Cancer Risk.The American journal of hospice & palliative care · 2018Observational
- Mainstreaming genetics in palliative care: barriers and suggestions for clinical genetic services.Journal of community genetics · 2018Article
- Issues related to family history of cancer at the end of life: a palliative care providers' survey.Familial cancer · 2018Article
- Inclusion of diverse populations in genomic research and health services: Genomix workshop report.Journal of community genetics · 2017Article
- The Spectrum of Caregiving in Palliative Care for Serious, Advanced, Rare Diseases: Key Issues and Research Directions.Journal of palliative medicine · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients are commonly referred to cancer genetics services when all affected family members are deceased. This makes genetic testing and risk assessment more difficult, reducing the benefit from screening and prophylactic treatment.
methodsObservational, retrospective, cohort study of 508 randomly selected patients referred to a regional cancer genetics unit, using review of case notes to explore whether a simple clinical "3, 2, 1" family history rule could have been used to improve timely and appropriate referrals for genetic assessment. The 3, 2, 1 criteria are: three affected relatives with the same/associated cancers, across two generations, with at least one person affected age <50 years.
resultsMost (71% [362]) genetic risk assessment referrals were in unaffected individuals and 22% (80) of these were referred after all affected family members had died, including 24% (19) who lost their last remaining affected relative in the previous year. Most (59% [301]) referrals met all 3, 2, 1 criteria, and 67% of these could have been made earlier in clinical practice. A further 23% (115) met two of the three criteria.
conclusionUsing a simple "3, 2, 1" family rule in cancer care and particularly in palliative care could enable earlier cancer genetic risk assessment for unaffected relatives, improving the potential to benefit from targeted screening and intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.