ArticleNanomedicine (London, England)2014
Targeting pancreatic cancer with magneto-fluorescent theranostic gold nanoshells.
Article in Nanomedicine (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 70 citations in OpenAlex.
- Nano-Drug Delivery Systems Targeting CAFs: A Promising Treatment for Pancreatic Cancer.International journal of nanomedicine · 2024Review
- Nanotechnology in diagnosis and therapy of gastrointestinal cancer.World journal of clinical cases · 2022Review
- Optimization of Gold Nanorod Features for the Enhanced Performance of Plasmonic Nanocavity Arrays.ACS omega · 2021Article
- Polymer coated gold nanoshells for combinational photochemotherapy of pancreatic cancer with gemcitabine.Scientific reports · 2021Article
- National Cancer Institute Alliance for nanotechnology in cancer-Catalyzing research and translation toward novel cancer diagnostics and therapeutics.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2019Review
- Biological Effects of Nanoparticles on Macrophage Polarization in the Tumor Microenvironment.Nanotheranostics · 2019Review
- NIR fluorescence-guided tumor surgery: new strategies for the use of indocyanine green.International journal of nanomedicine · 2019Review
- Silica-based organic-inorganic hybrid nanoparticles and nanoconjugates for improved anticancer drug delivery.Engineering in life sciences · 2018Review
- Big Potential from Small Agents: Nanoparticles for Imaging-Based Companion Diagnostics.ACS nano · 2018Review
- Theranostic Gold Nanoantennas for Simultaneous Multiplexed Raman Imaging of Immunomarkers and Photothermal Therapy.ACS omega · 2017Article
- Protease-Sensitive Nanomaterials for Cancer Therapeutics and Imaging.Industrial & engineering chemistry research · 2017Review
- Near Infrared Fluorescence Imaging in Nano-Therapeutics and Photo-Thermal Evaluation.International journal of molecular sciences · 2017Review
- Gold nanoparticles enlighten the future of cancer theranostics.International journal of nanomedicine · 2017Review
- Molecular Imaging of Pancreatic Cancer with Antibodies.Molecular pharmaceutics · 2016Review
- Advances in cancer research using gold nanoparticles mediated photothermal ablation.Clujul medical (1957) · 2016Review
- Targeted polyethylene glycol gold nanoparticles for the treatment of pancreatic cancer: from synthesis to proof-of-concept in vitro studies.International journal of nanomedicine · 2016Article
- Clostridium perfringens enterotoxin C-terminal domain labeled to fluorescent dyes for in vivo visualization of micrometastatic chemotherapy-resistant ovarian cancer.International journal of cancer · 2015Article
- Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy.Nano letters · 2015Article
- GEM-loaded magnetic albumin nanospheres modified with cetuximab for simultaneous targeting, magnetic resonance imaging, and double-targeted thermochemotherapy of pancreatic cancer cells.International journal of nanomedicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 5 institutions in 2 countries.
Funding
Abstract
aimWe report a magneto-fluorescent theranostic nanocomplex targeted to neutrophil gelatinase-associated lipocalin (NGAL) for imaging and therapy of pancreatic cancer. MATERIALS &
methodsGold nanoshells resonant at 810 nm were encapsulated in silica epilayers doped with iron oxide and the near-infrared (NIR) dye indocyanine green, resulting in theranostic gold nanoshells (TGNS), which were subsequently conjugated with antibodies targeting NGAL in AsPC-1-derived xenografts in nude mice.
resultsAnti-NGAL-conjugated TGNS specifically targeted pancreatic cancer cells in vitro and in vivo providing contrast for both NIR fluorescence and T2-weighted MRI with higher tumor contrast than can be obtained using long-circulating, but nontargeted, PEGylated nanoparticles. The nanocomplexes also enabled highly specific cancer cell death via NIR photothermal therapy in vitro.
conclusionTGNS with embedded NIR and magnetic resonance contrasts can be specifically targeted to pancreatic cancer cells with expression of early disease marker NGAL, and enable molecularly targeted imaging and photothermal therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.