ArticleBrain connectivity2013
Resting-state networks and the functional connectome of the human brain in agenesis of the corpus callosum.
Article in Brain connectivity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 57 citations in OpenAlex.
- Long-range axon branching: contributions to brain network plasticity and repair.Nature reviews. Neuroscience · 2026Review
- Connectomic and behavioural alterations in creatine transporter deficiency are partially normalized by gene therapy.Brain : a journal of neurology · 2026Article
- Structure-function coupling in highly sampled individual brains.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The relationship between interhemispheric homotopic functional connectivity and left-right difference of intrahemispheric functional integration in the human brain.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Identifying the distinct spectral dynamics of laminar-specific interhemispheric connectivity with bilateral line-scanning fMRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Heterotopic connectivity of callosal dysgenesis in mice and humans.Frontiers in neuroscience · 2023Article
- Social anxiety disorder in an adolescent with agenesis of the corpus callosum: a case report.BMC psychiatry · 2022Article
- Functional cortical associations and their intraclass correlations and heritability as revealed by the fMRI Human Connectome Project.Experimental brain research · 2022Article
- Predicting Functional Connectivity From Observed and Latent Structural ConnectivityFrontiers in neuroscience · 2022Article
- Inner Hemispheric and Interhemispheric Connectivity Balance in the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Effect of corpus callosum agenesis on the language network in children and adolescents.Brain structure & function · 2021Article
- Corpus callosum dysgenesis causes novel patterns of structural and functional brain connectivity.Brain communications · 2021Article
- Reduced Inter-hemispheric Resting State Functional Connectivity and Its Association With Social Deficits in Autism.Frontiers in psychiatry · 2021Review
- Altered structural connectivity networks in a mouse model of complete and partial dysgenesis of the corpus callosum.NeuroImage · 2020Article
- An Atypical Sulcal Pattern in Children with Disorders of the Corpus Callosum and Its Relation to Behavioral Outcomes.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Dynamic Interhemispheric Desynchronization in Marmosets and Humans With Disorders of the Corpus Callosum.Frontiers in neural circuits · 2020Article
- Article
- Functional Integration Between the Two Brain Hemispheres: Evidence From the Homotopic Functional Connectivity Under Resting State.Frontiers in neuroscience · 2020Review
- The structural basis for interhemispheric functional connectivity: Evidence from individuals with agenesis of the corpus callosum.NeuroImage. Clinical · 2020Article
- The homotopic connectivity of the functional brain: a meta-analytic approach.Scientific reports · 2019Article
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Authors and funding
11 authors at 1 institution in 2 countries.
Funding
Abstract
The corpus callosum is the largest white matter fiber bundle connecting the two cerebral hemispheres. In this work, we investigate the effect of callosal dysgenesis on functional magnetic resonance imaging (fMRI) resting-state networks and the functional connectome. Since alternate commissural routes between the cerebral hemispheres exist, we hypothesize that bilateral cortical networks can still be maintained in partial or even complete agenesis of the corpus callosum (AgCC). However, since these commissural routes are frequently indirect, requiring polysynaptic pathways, we hypothesize that quantitative measurements of interhemispheric functional connectivity in bilateral networks will be reduced in AgCC compared with matched controls, especially in the most highly interconnected cortical regions that are the hubs of the connectome. Seventeen resting-state networks were extracted from fMRI of 11 subjects with partial or complete AgCC and 11 matched controls. The results show that the qualitative organization of resting-state networks is very similar between controls and AgCC. However, interhemispheric functional connectivity of precuneus, posterior cingulate cortex, and insular-opercular regions was significantly reduced in AgCC. The preserved network organization was confirmed with a connectomic analysis of the resting-state fMRI data, showing five functional modules that are largely consistent across the control and AgCC groups. Hence, the reduction or even complete absence of callosal connectivity does not affect the qualitative organization of bilateral resting-state networks or the modular organization of the functional connectome, although quantitatively reduced functional connectivity can be demonstrated by measurements within bilateral cortical hubs, supporting the hypothesis that indirect polysynaptic pathways are utilized to preserve interhemispheric temporal synchrony.
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