ArticleBioMed research international2013
Anticestodal activity of endophytic Pestalotiopsis sp. on protoscoleces of hydatid cyst Echinococcus granulosus.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Effect of aminomix-1 solution as an in vitro scolicidal agent on the bile ducts and liver in rats: a controlled experimental animal study.Sao Paulo medical journal = Revista paulista de medicina · 2026Article
- Evaluation of structural changes ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2023Article
- An Inventory of Anthelmintic Plants across the Globe.Pathogens (Basel, Switzerland) · 2023Review
- Herbal Medicines against Hydatid Disease: A Systematic Review (2000-2021).Life (Basel, Switzerland) · 2022Review
- In Vitro Antigenotoxic, Antihelminthic and Antioxidant Potentials Based on the Extracted Metabolites from Lichen,Pharmaceutics · 2020Article
- Ultrastructural changes in hydatid cyst walls obtained from human cases, exposed to different therapeutic approaches.Parasitology research · 2019Article
- Anti-inflammatory action of ambuic acid, a natural product isolated from the solid culture ofExperimental and therapeutic medicine · 2018Article
- Progress in the pharmacological treatment of human cystic and alveolar echinococcosis: Compounds and therapeutic targets.PLoS neglected tropical diseases · 2018Article
- Endophytic Mycoflora and Their Bioactive Compounds from Azadirachta Indica: A Comprehensive Review.Journal of fungi (Basel, Switzerland) · 2018Review
- Scolicidal agents for protoscolices ofJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2017Review
- Medicinal Plants, Herbal Compounds, and Other Natural Products Used againstIranian journal of parasitologyReview
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4 authors.
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Abstract
Surgery is still the main treatment in hydatidosis caused by Echinococcus, which is a global health problem in human and animals. So, there is need for some natural protoscolicidal agents for instillation to prevent their reoccurrence at therapeutic doses. In this present investigation, anticestodal activity of one of the endophytic fungi Pestalotiopsis sp. from Neem plant was observed on protoscoleces of hydatid cysts of Echinococcus granulosus. Viability of protoscoleces was confirmed by 0.1% aqueous eosin red stain method, where mortality was observed at different concentrations with respect to time. An average anticestodal activity was observed with different endophytic fungal strains, that is, Nigrospora (479 ± 2.9), Colletotrichum (469 ± 25.8), Fusarium (355 ± 14.5), and Chaetomium (332 ± 28.3) showing 64 to 70% protoscolicidal activity, except Pestalotiopsis sp. (581 ± 15.0), which showed promising scolicidal activity up to 97% mortality just within 30 min of incubation. These species showed significant reduction in viability of protoscoleces. This is the first report on the scolicidal activity of endophytic Pestalotiopsis sp. We conclude that ultrastructural changes in protoscoleces were due to endophytic extract suggesting that there may be some bioactive compounds that have selective action on the tegument layer of protoscoleces. As compared with that of standard drug used, endophytic species of Neem plant shows significant anticestodal activity.
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