ArticleEuropean heart journal. Acute cardiovascular care2013
Heart failure due to 'stress cardiomyopathy': a severe manifestation of the opioid withdrawal syndrome.
Article in European heart journal. Acute cardiovascular care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- A Case Report on Opioid Withdrawal-Induced Stress Cardiomyopathy and a Review of the Current Literature.Case reports in cardiology · 2026Article
- Methadone-Induced Toxicity-An Unexpected Challenge for the Brain and Heart in ICU Settings: Case Report and Review of the Literature.Life (Basel, Switzerland) · 2025Article
- Trends in Psychotropic Drug-Implicated Cardiovascular Mortality: Patterns in U.S. Mortality, 1999-2020.American journal of preventive medicine · 2023Article
- Can Breaking Heroin Addiction Lead to a Broken Heart? A Case of Reverse Takotsubo Cardiomyopathy in a Patient With Heroin Withdrawal.Texas Heart Institute journal · 2023Article
- Case report: The lesson from opioid withdrawal symptoms mimicking paraganglioma recurrence during opioid deprescribing in cancer pain.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Cardiovascular Mortality Gap Between the United States and Other High Life Expectancy Countries in 2000-2016.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022Article
- Buprenorphine withdrawal induced takotsubo cardiomyopathy: A series of unfortunate events.Journal of cardiology cases · 2022Article
- Acute right ventricular failure: a novel presentation of methadone-induced cardiotoxicity.BMJ case reports · 2020Article
- Stress Cardiomyopathy (Takotsubo syndrome) Following Accidental Methadone Poisoning; Report of Two Pediatric Cases.Archives of academic emergency medicine · 2019Article
- Dependence, withdrawal and rebound of CNS drugs: an update and regulatory considerations for new drugs development.Brain communications · 2019Review
- Stress Cardiomyopathy Diagnosis and Treatment: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2018Review
- Takotsubo cardiomyopathy: A potentially serious trap (Data from the International Takotsubo Cardiomyopathy Registry).Global cardiology science & practice · 2015Article
- Safety issues of current analgesics: an update.Clujul medical (1957) · 2015Review
- Changes in levels of angiotensin II and its receptors in a model of inverted stress-induced cardiomyopathy.European journal of medical research · 2014Article
- Apical ballooning with mid-ventricular obstruction: the many faces of Takotsubo cardiomyopathy.Global cardiology science & practice · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Takotsubo cardiomyopathy (TTC) is a transient left ventricular (LV) dysfunction due to akinesia of the LV mid-apical segments ('apical ballooning') in the absence of critical coronary stenoses which can be complicated in the acute phase by heart failure, mitral regurgitation, life-threatening ventricular arrhythmias, or apical LV thrombosis. The syndrome is typically precipitated by intense emotional or physical stress; however, other causes of sympathetic overstimulation including administration of exogenous sympathomimetics or withdrawal of sympathetic antagonists can trigger TTC. We report the case of a patient who unexpectedly developed an 'apical ballooning' with severe reduction in the LV systolic function and heart failure after the withdrawal of methadone. The case supports the concept that increased sympathetic activity secondary to opioids withdrawal can trigger a stress-induced severe LV dysfunction. Physicians should be aware that the abrupt discontinuation of a long-term therapy with opioids may lead to serious cardiac complications. The administration of clonidine may be considered to prevent early clinical manifestations of addictive withdrawal, including TTC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.