ArticleEvolutionary applications2013
Fight evolution with evolution: plasmid-dependent phages with a wide host range prevent the spread of antibiotic resistance.
Article in Evolutionary applications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- A Biological Approach to Antimicrobial Resistance in New and Old Bacterial Pathogens.Pathogens (Basel, Switzerland) · 2026Review
- The pig as a preclinical model for human phage therapy of polybacterial enteric infections.Frontiers in microbiology · 2026Article
- The hospital sink drain microbiome as a melting pot for AMR transmission to nosocomial pathogens.npj antimicrobials and resistance · 2025Review
- Phage-Antibiotic Combinations for Pseudomonas: Successes in the Clinic and In Vitro Tenuously Connected.Microbial biotechnology · 2025Review
- Interactions and evolutionary relationships among bacterial mobile genetic elements.Nature reviews. Microbiology · 2025Review
- Phage therapy for Klebsiella pneumoniae: Understanding bacteria-phage interactions for therapeutic innovations.PLoS pathogens · 2025Review
- Article
- Rediscovering plasmid-dependent phages.Nature reviews. Microbiology · 2024Article
- Phage predation accelerates the spread of plasmid-encoded antibiotic resistance.Nature communications · 2024Article
- Diverse and abundant phages exploit conjugative plasmids.Nature communications · 2024Article
- Review
- New Approaches to Tackling Intractable Issues in Infectious Disease.Microorganisms · 2024Review
- Isolation and characterization of novel plasmid-dependent phages infecting bacteria carrying diverse conjugative plasmids.Microbiology spectrum · 2024Article
- Bacteriophage therapy for drug-resistantFrontiers in cellular and infection microbiology · 2024Review
- Diverse and abundant phages exploit conjugative plasmids.bioRxiv : the preprint server for biology · 2023Article
- Urinary Plasmids Reduce Permissivity to Coliphage Infection.Microbiology spectrum · 2023Article
- A mathematician's guide to plasmids: an introduction to plasmid biology for modellers.Microbiology (Reading, England) · 2023Review
- Characterization and comprehensive genome analysis of novel bacteriophage, vB_Kpn_ZCKp20p, with lytic and anti-biofilm potential against clinical multidrug-resistantFrontiers in cellular and infection microbiology · 2023Article
- The presence of plasmids in bacterial hosts alters phage isolation and infectivity.ISME communications · 2022Article
- Evolutionary Dynamics between Phages and Bacteria as a Possible Approach for Designing Effective Phage Therapies against Antibiotic-Resistant Bacteria.Antibiotics (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emergence of pathogenic bacteria resistant to multiple antibiotics is a serious worldwide public health concern. Whenever antibiotics are applied, the genes encoding for antibiotic resistance are selected for within bacterial populations. This has led to the prevalence of conjugative plasmids that carry resistance genes and can transfer themselves between diverse bacterial groups. In this study, we investigated whether it is feasible to attempt to prevent the spread of antibiotic resistances with a lytic bacteriophage, which can replicate in a wide range of gram-negative bacteria harbouring conjugative drug resistance-conferring plasmids. The counter-selection against the plasmid was shown to be effective, reducing the frequency of multidrug-resistant bacteria that formed via horizontal transfer by several orders of magnitude. This was true also in the presence of an antibiotic against which the plasmid provided resistance. Majority of the multiresistant bacteria subjected to phage selection also lost their conjugation capability. Overall this study suggests that, while we are obligated to maintain the selection for the spread of the drug resistances, the 'fight evolution with evolution' approach could help us even out the outcome to our favour.
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