ReviewFrontiers in immunology2013
The application of next generation sequencing to the understanding of antibody repertoires.
Review in Frontiers in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- The rise of big data: deep sequencing-driven computational methods are transforming the landscape of synthetic antibody design.Journal of biomedical science · 2024Review
- Article
- AI/ML combined with next-generation sequencing of VHH immune repertoires enables the rapid identification ofFrontiers in molecular biosciences · 2023Article
- Cognizance of Molecular Methods for the Generation of Mutagenic Phage Display Antibody Libraries for Affinity Maturation.International journal of molecular sciences · 2019Review
- Efficient Selection of Antibodies Reactive to Homologous Epitopes on Human and Mouse Hepatocyte Growth Factors by Next-Generation Sequencing-Based Analysis of the B Cell Repertoire.International journal of molecular sciences · 2019Article
- Advancing computational biology and bioinformatics research through open innovation competitions.PloS one · 2019Article
- Many Routes to an Antibody Heavy-Chain CDR3: Necessary, Yet Insufficient, for Specific Binding.Frontiers in immunology · 2018Article
- A Haystack Heuristic for Autoimmune Disease Biomarker Discovery Using Next-Gen Immune Repertoire Sequencing Data.Scientific reports · 2017Article
- Application of next generation sequencing for the detection of human viral pathogens in clinical specimens.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2017Article
- Naïve Human Antibody Libraries for Infectious Diseases.Advances in experimental medicine and biology · 2017Review
- High-Throughput Sequencing-Based Immune Repertoire Study during Infectious Disease.Frontiers in immunology · 2016Review
- Predominant structural configuration of natural antibody repertoires enables potent antibody responses against protein antigens.Scientific reports · 2015Article
- Sequencing the functional antibody repertoire--diagnostic and therapeutic discovery.Nature reviews. Rheumatology · 2015Review
- Antibody-specific model of amino acid substitution for immunological inferences from alignments of antibody sequences.Molecular biology and evolution · 2015Article
- Variation of the specificity of the human antibody responses after tick-borne encephalitis virus infection and vaccination.Journal of virology · 2014Article
- Single-cell and deep sequencing of IgG-switched macaque B cells reveal a diverse Ig repertoire following immunization.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- High-throughput sequencing of natively paired antibody chains provides evidence for original antigenic sin shaping the antibody response to influenza vaccination.Clinical immunology (Orlando, Fla.) · 2014Article
- High-throughput sequencing of human immunoglobulin variable regions with subtype identification.PloS one · 2014Article
- Epitope-specific antibody levels in tuberculosis: biomarkers of protection, disease, and response to treatment.Frontiers in immunology · 2014Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the decade since the human genome sequence was declared complete, the development of next generation sequencing (NGS) or "deep" sequencing to deliver cost-effective genomic sequencing has influenced advances beyond its primary application and changed the research landscape in many other areas. This review will survey recent applications of NGS which have broadened the understanding of natural antibody repertoires (the "antibodyome") and how these evolve in response to viral infection. We will also report examples where deep sequencing of binding populations, derived from both natural and synthetic repertoires, have been used to benefit antibody engineering. This knowledge will ultimately lead to the design of more effective biological drugs and vaccines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.