ArticleFrontiers in physiology2013
Role of Per1 and the mineralocorticoid receptor in the coordinate regulation of αENaC in renal cortical collecting duct cells.
Article in Frontiers in physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Current perspective on circadian function of the kidney.American journal of physiology. Renal physiology · 2024Review
- Aldosterone: Renal Action and Physiological Effects.Comprehensive Physiology · 2023Article
- Clock genes rescue nphp mutations in zebrafish.Human molecular genetics · 2022Article
- Knockout of the Circadian Clock Protein PER1 (Period1) Exacerbates Hypertension and Increases Kidney Injury in Dahl Salt-Sensitive Rats.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Sleep Restriction and Recurrent Circadian Disruption Differentially Affects Blood Pressure, Sodium Retention, and Aldosterone Secretion.Frontiers in physiology · 2022Article
- Aldosterone-Regulated Sodium Transport and Blood Pressure.Frontiers in physiology · 2022Review
- Circadian Rhythm Effects on the Molecular Regulation of Physiological Systems.Comprehensive Physiology · 2021Review
- Salt sensitivity of volume and blood pressure in a mouse with globally reduced ENaC γ-subunit expression.American journal of physiology. Renal physiology · 2021Article
- Circadian Clock Genes in Diabetic Kidney Disease (DKD).Current diabetes reports · 2019Review
- Direct and indirect inhibition of the circadian clock protein Per1: effects on ENaC and blood pressure.American journal of physiology. Renal physiology · 2019Article
- Review
- Female C57BL/6J mice lacking the circadian clock protein PER1 are protected from nondipping hypertension.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Chronobiology in nephrology: the influence of circadian rhythms on renal handling of drugs and renal disease treatment.International urology and nephrology · 2018Review
- Circadian rhythms and the kidney.Nature reviews. Nephrology · 2018Review
- Circadian regulation of renal function.Free radical biology & medicine · 2018Review
- Circadian regulation of kidney function: finding a role for Bmal1.American journal of physiology. Renal physiology · 2018Review
- Desoxycorticosterone pivalate-salt treatment leads to non-dipping hypertension in Per1 knockout mice.Acta physiologica (Oxford, England) · 2017Article
- Molecular basis of circadian rhythmicity in renal physiology and pathophysiology.Experimental physiology · 2016Review
- The Circadian Clock in the Regulation of Renal Rhythms.Journal of biological rhythms · 2015Review
- Transcriptional regulation of NHE3 and SGLT1 by the circadian clock protein Per1 in proximal tubule cells.American journal of physiology. Renal physiology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Renal function and blood pressure (BP) exhibit a circadian pattern of variation, but the molecular mechanism underlying this circadian regulation is not fully understood. We have previously shown that the circadian clock protein Per1 positively regulates the basal and aldosterone-mediated expression of the alpha subunit of the renal epithelial sodium channel (αENaC). The mechanism of this regulation has not been determined however. To further elucidate the mechanism of mineralocorticoid receptor (MR) and Per1 action, site-directed mutagenesis, DNA pull-down assays and chromatin immunoprecipitation (ChIP) methods were used to investigate the coordinate regulation of αENaC by Per1 and MR. Mutation of two circadian response E-boxes in the human αENaC promoter abolished both basal and aldosterone-mediated promoter activity. DNA pull down assays demonstrated the interaction of both MR and Per1 with the E-boxes from the αENaC promoter. These observations were corroborated by ChIP experiments showing increased occupancy of MR and Per1 on an E-box of the αENaC promoter in the presence of aldosterone. This is the first report of an aldosterone-mediated increase in Per1 on a target gene promoter. Taken together, these results demonstrate the novel finding that Per1 and MR mediate the aldosterone response of αENaC through DNA/protein interaction in renal collecting duct cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.