ArticleFrontiers in systems neuroscience2013
Shaping the aging brain: role of auditory input patterns in the emergence of auditory cortical impairments.
Article in Frontiers in systems neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Preserved topography, lateralization, selectivity, and functional connectivity of the language network in older brains.Nature communications · 2026Article
- Parallel Age-Related Cochlear Neural Degeneration and Cortical Gain Adaptation in Normal-Hearing Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Novelty detection in an auditory oddball task on freely moving rats.Communications biology · 2023Article
- Psychosis spectrum illnesses as disorders of prefrontal critical period plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Hearing loss and brain plasticity: the hyperactivity phenomenon.Brain structure & function · 2021Review
- Regulation of auditory plasticity during critical periods and following hearing loss.Hearing research · 2020Review
- Age-related neural dedifferentiation and cognition.Current opinion in behavioral sciences · 2020Article
- Modifying the Adult Rat Tonotopic Map with Sound Exposure Produces Frequency Discrimination Deficits That Are Recovered with Training.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Aging and Central Auditory Disinhibition: Is It a Reflection of Homeostatic Downregulation or Metabolic Vulnerability?Brain sciences · 2019Review
- Neural Dedifferentiation in the Aging Brain.Trends in cognitive sciences · 2019Review
- Evidence of Hyperacusis in Adult Rats Following Non-traumatic Sound Exposure.Frontiers in systems neuroscience · 2019Article
- The space where aging acts: focus on the GABAergic synapse.Aging cell · 2017Review
- Dynamic Brains and the Changing Rules of Neuroplasticity: Implications for Learning and Recovery.Frontiers in psychology · 2017Article
- The Neural Consequences of Age-Related Hearing Loss.Trends in neurosciences · 2016Review
- Effect of signal to noise ratio on the speech perception ability of older adults.Medical journal of the Islamic Republic of Iran · 2016Article
- The effects of hearing loss on neural processing and plasticity.Frontiers in systems neuroscience · 2015Article
- Article
- Trajectory of the main GABAergic interneuron populations from early development to old age in the rat primary auditory cortex.Frontiers in neuroanatomy · 2014Article
- Brain plasticity-based therapeutics.Frontiers in human neuroscience · 2014Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age-related impairments in the primary auditory cortex (A1) include poor tuning selectivity, neural desynchronization, and degraded responses to low-probability sounds. These changes have been largely attributed to reduced inhibition in the aged brain, and are thought to contribute to substantial hearing impairment in both humans and animals. Since many of these changes can be partially reversed with auditory training, it has been speculated that they might not be purely degenerative, but might rather represent negative plastic adjustments to noisy or distorted auditory signals reaching the brain. To test this hypothesis, we examined the impact of exposing young adult rats to 8 weeks of low-grade broadband noise on several aspects of A1 function and structure. We then characterized the same A1 elements in aging rats for comparison. We found that the impact of noise exposure on A1 tuning selectivity, temporal processing of auditory signal and responses to oddball tones was almost indistinguishable from the effect of natural aging. Moreover, noise exposure resulted in a reduction in the population of parvalbumin inhibitory interneurons and cortical myelin as previously documented in the aged group. Most of these changes reversed after returning the rats to a quiet environment. These results support the hypothesis that age-related changes in A1 have a strong activity-dependent component and indicate that the presence or absence of clear auditory input patterns might be a key factor in sustaining adult A1 function.
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