ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2013
From simple to detailed models for cell polarization.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed.
- Balanced contractility and adhesion drive polarization in a minimal elastic actomyosin network.PLoS computational biology · 2026Article
- Using Floquet theory to unravel far-from equilibrium dynamics in reaction-diffusion systems.PNAS nexus · 2026Article
- Modeling actin-microtubule crosstalk in migrating cells.Biophysical journal · 2025Article
- Article
- Non-asymptotic transients away from steady states determine cellular responsiveness to dynamic spatial-temporal signals.PLoS computational biology · 2023Article
- Spatiotemporal Coordination of Rac1 and Cdc42 at the Whole Cell Level during Cell Ruffling.Cells · 2023Article
- Polarity and mixed-mode oscillations may underlie different patterns of cellular migration.Scientific reports · 2023Article
- Article
- Sensing the shape of a cell with reaction diffusion and energy minimization.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Exploring the influence of cytosolic and membrane FAK activation on YAP/TAZ nuclear translocation.Biophysical journal · 2021Article
- Comparative mapping of crawling-cell morphodynamics in deep learning-based feature space.PLoS computational biology · 2021Article
- Mass conservative reaction-diffusion systems describing cell polarity.Mathematical methods in the applied sciences · 2021Article
- Spots, stripes, and spiral waves in models for static and motile cells : GTPase patterns in cells.Journal of mathematical biology · 2021Article
- Article
- Membrane Tension Can Enhance Adaptation to Maintain Polarity of Migrating Cells.Biophysical journal · 2020Article
- Article
- Article
- A hybrid stochastic-deterministic mechanochemical model of cell polarization.Molecular biology of the cell · 2020Article
- Review
- Simple Rho GTPase Dynamics Generate a Complex Regulatory Landscape Associated with Cell Shape.Biophysical journal · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Many mathematical models have been proposed for the process of cell polarization. Some of these are 'functional models' that capture a class of dynamical behaviour, whereas others are derived from features of signalling molecules. Some mechanistic models are detailed, and therefore complex, whereas others are simplified. Each type contributes to our understanding of cell polarization. However, the huge variety at different levels of detail makes comparisons challenging. Here, we provide examples of both elementary and more detailed models for polarization. We also display how a recent mathematical method, local perturbation analysis, can provide an appropriate tool for such comparisons. This technique simplifies and speeds up the model development process by revealing the effect of model extensions, parameter variations and in silico manipulations such as knock-out or over-expression of key molecules. Finally, simulations in both one dimension and two dimensions, and particularly in deforming two-dimensional 'cells', can highlight behaviour not captured by traditional simulation methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.