ArticleG3 (Bethesda, Md.)2013
Cell-type-specific transcriptional profiles of the dimorphic pathogen Penicillium marneffei reflect distinct reproductive, morphological, and environmental demands.
Article in G3 (Bethesda, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Identification of Homeobox Transcription Factors in a Dimorphic FungusJournal of fungi (Basel, Switzerland) · 2024Article
- Identification of glutathione metabolic genes from a dimorphic fungus Talaromyces marneffei and their gene expression patterns under different environmental conditions.Scientific reports · 2023Article
- An Overlooked and Underrated Endemic Mycosis-Talaromycosis and the Pathogenic Fungus Talaromyces marneffei.Clinical microbiology reviews · 2023Review
- In vitro antifungal susceptibility of Sporothrix globosa isolates from Jilin Province, northeastern China: comparison of yeast and mycelial phases.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Bioinformatic analysis of the pathogenic mechanism of talaromyces marneffei infection.Medicine · 2020Article
- Sixty Years from Segretain's Description: What Have We Learned and Should Learn About the Basic Mycology of Talaromyces marneffei?Mycopathologia · 2019Article
- Diversity of Cell Wall Related Proteins in Human Pathogenic Fungi.Journal of fungi (Basel, Switzerland) · 2017Article
- Acute Penicillium marneffei infection stimulates host M1/M2a macrophages polarization in BALB/C mice.BMC microbiology · 2017Article
- Review
- Iron acquisition in fungal pathogens of humans.Metallomics : integrated biometal science · 2017Review
- Extensive Metabolic Remodeling Differentiates Non-pathogenic and Pathogenic Growth Forms of the Dimorphic PathogenFrontiers in cellular and infection microbiology · 2017Article
- Global transcriptional analysis suggests Lasiodiplodia theobromae pathogenicity factors involved in modulation of grapevine defensive response.BMC genomics · 2016Article
- Siderophore Biosynthesis but Not Reductive Iron Assimilation Is Essential for the Dimorphic Fungus Nomuraea rileyi Conidiation, Dimorphism Transition, Resistance to Oxidative Stress, Pigmented Microsclerotium Formation, and Virulence.Frontiers in microbiology · 2016Article
- Intracellular growth is dependent on tyrosine catabolism in the dimorphic fungal pathogen Penicillium marneffei.PLoS pathogens · 2015Article
- Thermally Dimorphic Human Fungal Pathogens--Polyphyletic Pathogens with a Convergent Pathogenicity Trait.Cold Spring Harbor perspectives in medicine · 2014Review
- Signature gene expression reveals novel clues to the molecular mechanisms of dimorphic transition in Penicillium marneffei.PLoS genetics · 2014Article
- Morphotype transition and sexual reproduction are genetically associated in a ubiquitous environmental pathogen.PLoS pathogens · 2014Article
- Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Penicillium marneffei is an opportunistic human pathogen endemic to Southeast Asia. At 25° P. marneffei grows in a filamentous hyphal form and can undergo asexual development (conidiation) to produce spores (conidia), the infectious agent. At 37° P. marneffei grows in the pathogenic yeast cell form that replicates by fission. Switching between these growth forms, known as dimorphic switching, is dependent on temperature. To understand the process of dimorphic switching and the physiological capacity of the different cell types, two microarray-based profiling experiments covering approximately 42% of the genome were performed. The first experiment compared cells from the hyphal, yeast, and conidiation phases to identify "phase or cell-state-specific" gene expression. The second experiment examined gene expression during the dimorphic switch from one morphological state to another. The data identified a variety of differentially expressed genes that have been organized into metabolic clusters based on predicted function and expression patterns. In particular, C-14 sterol reductase-encoding gene ergM of the ergosterol biosynthesis pathway showed high-level expression throughout yeast morphogenesis compared to hyphal. Deletion of ergM resulted in severe growth defects with increased sensitivity to azole-type antifungal agents but not amphotericin B. The data defined gene classes based on spatio-temporal expression such as those expressed early in the dimorphic switch but not in the terminal cell types and those expressed late. Such classifications have been helpful in linking a given gene of interest to its expression pattern throughout the P. marneffei dimorphic life cycle and its likely role in pathogenicity.
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