ArticleJournal of immunology (Baltimore, Md. : 1950)2013
Suprachiasmatic astrocytes modulate the circadian clock in response to TNF-α.
Article in Journal of immunology (Baltimore, Md. : 1950), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 62 citations in OpenAlex.
- Convergent Astrocytic Failure in Parkinson's Disease: A System-Level Model of Pathogenesis and Treatment.Molecular neurobiology · 2026Review
- Neuroinflammatory suppression of astrocytic BMAL1 defines a selective reactive astrocyte program.Journal of neuroinflammation · 2026Article
- Unravelling the link between circadian clock genes and brain tumors: From pathological disruptions to potential therapeutic interventions.Frontiers in pharmacology · 2025Review
- The cytokine receptor Fn14 is a molecular brake on neuronal activity that mediates circadian functionbioRxiv : the preprint server for biology · 2024Article
- Astrocyte regulation of extracellular space parameters across the sleep-wake cycle.Frontiers in cellular neuroscience · 2024Review
- Disrupting circadian control of peripheral myogenic reactivity mitigates cardiac injury following myocardial infarction.Cardiovascular research · 2023Article
- The Circadian Clock of Polarized Microglia and Its Interaction with Mouse Brain Oscillators.Cellular and molecular neurobiology · 2023Article
- Reduction in vasopressin cells in the suprachiasmatic nucleus in mice increases anxiety and alters fluid intake.Hormones and behavior · 2021Article
- Astrocyte Circadian Timekeeping in Brain Health and Neurodegeneration.Advances in experimental medicine and biology · 2021Article
- Circadian Rhythms in Bacterial Sepsis Pathology: What We Know and What We Should Know.Frontiers in cellular and infection microbiology · 2021Review
- Systems and Circuits Linking Chronic Pain and Circadian Rhythms.Frontiers in neuroscience · 2021Review
- The interaction of the circadian and immune system: Desynchrony as a pathological outcome to traumatic brain injury.Neurobiology of sleep and circadian rhythms · 2020Review
- Circadian disruption promotes tumor-immune microenvironment remodeling favoring tumor cell proliferation.Science advances · 2020Article
- Deletion of astrocytic BMAL1 results in metabolic imbalance and shorter lifespan in mice.Glia · 2020Article
- The wrinkling of time: Aging, inflammation, oxidative stress, and the circadian clock in neurodegeneration.Neurobiology of disease · 2020Review
- Circadian regulation of astrocyte function: implications for Alzheimer's disease.Cellular and molecular life sciences : CMLS · 2020Review
- Differential Thermoregulatory and Inflammatory Patterns in the Circadian Response to LPS-Induced Septic Shock.Frontiers in cellular and infection microbiology · 2020Article
- Circuit development in the master clock network of mammals.The European journal of neuroscience · 2020Review
- Host circadian rhythms are disrupted during malaria infection in parasite genotype-specific manners.Scientific reports · 2019Article
- H. pylori infection induced BMAL1 expression and rhythm disorder aggravate gastric inflammation.EBioMedicine · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The immune and the circadian systems interact in a bidirectional fashion. The master circadian oscillator, located in the suprachiasmatic nuclei (SCN) of the hypothalamus, responds to peripheral and local immune stimuli, such as proinflammatory cytokines and bacterial endotoxin. Astrocytes exert several immune functions in the CNS, and there is growing evidence that points toward a role of these cells in the regulation of circadian rhythms. The aim of this work was to assess the response of SCN astrocytes to immune stimuli, particularly to the proinflammatory cytokine TNF-α. TNF-α applied to cultures of SCN astrocytes from Per2(luc) knockin mice altered both the phase and amplitude of PER2 expression rhythms, in a phase-dependent manner. Furthermore, conditioned media from SCN astrocyte cultures transiently challenged with TNF-α induced an increase in Per1 expression in NIH 3T3 cells, which was blocked by TNF-α antagonism. In addition, these conditioned media could induce phase shifts in SCN PER2 rhythms and, when administered intracerebroventricularly, induced phase delays in behavioral circadian rhythms and SCN activation in control mice, but not in TNFR-1 mutants. In summary, our results show that TNF-α modulates the molecular clock of SCN astrocytes in vitro, and also that, in response to this molecule, SCN astrocytes can modulate clock gene expression in other cells and tissues, and induce phase shifts in a circadian behavioral output in vivo. These findings suggest a role for astroglial cells in the alteration of circadian timing by immune activation.
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