ArticleProceedings of the National Academy of Sciences of the United States of America2013
Postsynaptic neural activity regulates neuronal addition in the adult avian song control system.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Social Behavior and Neurogenesis.International journal of molecular sciences · 2026Review
- Adult neurogenesis is necessary for functional regeneration of a forebrain neural circuit.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Brain Gene Regulatory Networks Coordinate Nest Construction in Birds.Molecular biology and evolution · 2024Article
- Unilateral vocal nerve resection alters neurogenesis in the avian song system in a region-specific manner.PloS one · 2021Article
- Rapamycin blocks the neuroprotective effects of sex steroids in the adult birdsong system.Developmental neurobiology · 2019Article
- Seasonal changes in neuronal turnover in a forebrain nucleus in adult songbirds.The Journal of comparative neurology · 2019Article
- Three-dimensional (3D) brain microphysiological system for organophosphates and neurochemical agent toxicity screening.PloS one · 2019Article
- Dissociable Effects on Birdsong of Androgen Signaling in Cortex-Like Brain Regions of Canaries.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Concerted and mosaic evolution of functional modules in songbird brains.Proceedings. Biological sciences · 2017Article
- Article
- Neurogenesis in the adult avian song-control system.Cold Spring Harbor perspectives in biology · 2015Review
- Transsynaptic trophic effects of steroid hormones in an avian model of adult brain plasticity.Frontiers in neuroendocrinology · 2015Review
- Temporary inactivation of the anterior part of the bed nucleus of the stria terminalis blocks alarm pheromone-induced defensive behavior in rats.Frontiers in neuroscience · 2015Article
- Reactive neurogenesis in response to naturally occurring apoptosis in an adult brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Dissociable effects of social context on song and doublecortin immunoreactivity in male canaries.The European journal of neuroscience · 2014Article
- Differential effects of global versus local testosterone on singing behavior and its underlying neural substrate.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
A striking feature of the nervous system is that it shows extensive plasticity of structure and function that allows animals to adjust to changes in their environment. Neural activity plays a key role in mediating experience-dependent neural plasticity and, thus, creates a link between the external environment, the nervous system, and behavior. One dramatic example of neural plasticity is ongoing neurogenesis in the adult brain. The role of neural activity in modulating neuronal addition, however, has not been well studied at the level of neural circuits. The avian song control system allows us to investigate how activity influences neuronal addition to a neural circuit that regulates song, a learned sensorimotor social behavior. In adult white-crowned sparrows, new neurons are added continually to the song nucleus HVC (proper name) and project their axons to its target nucleus, the robust nucleus of the arcopallium (RA). We report here that electrical activity in RA regulates neuronal addition to HVC. Decreasing neural activity in RA by intracerebral infusion of the GABAA receptor agonist muscimol decreased the number of new HVC neurons by 56%. Our results suggest that postsynaptic electrical activity influences the addition of new neurons into a functional neural circuit in adult birds.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.