Evidence map›Paper›PMID 24062447›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2013

Epigenetic control of natural killer cell maturation by histone H2A deubiquitinase, MYSM1.

Vijayalakshmi Nandakumar, Yuchia Chou, Linda Zang, Xue F Huang, Si-Yi Chen

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 110 citations in OpenAlex.

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  18. Molecular Regulation of NK Cell Maturation.Frontiers in immunology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Vijayalakshmi NandakumarDepartment of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.
Yuchia Chou
Linda Zang
Xue F Huang
Si-Yi Chen
University of Southern California · US

Funding

Overcoming Immune Suppression to Enhance Tumor Vaccine EfficacyR01CA090427 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, SI-YI · 2002 to 2013
$3.1M
Developing novel adjuvants for HIV vaccinationR01AI084811 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, SI-YI · 2009 to 2013
$2.2M
HIV vaccination via inhibition of cytokine signaling inhibitorsR01AI068472 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, SI-YI · 2006 to 2010
$1.7M
A Novel Oncolytic HSP Vaccine for Systemic Tumor TherapyR01CA100841 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HUANG, XUE F · 2006 to 2010
$1.1M
Tumor Vaccination: Modulation of Inhibitory Signaling in Antigen-presenting cellsR01CA116677 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, SI-YI · 2006 to 2009
$988k
NCI NIH HHS CA100841NCI NIH HHS CA116677NCI NIH HHS R01 CA090427NCI NIH HHS R01CA090427NCI NIH HHS R01 CA100841NCI NIH HHS R01 CA116677NIAID NIH HHS AI068472NIAID NIH HHS AI08185NIAID NIH HHS AI084811NIAID NIH HHS R01 AI068472NIAID NIH HHS R01 AI084811
6 · The paper itself

Abstract

Histone modifications play critical roles in regulating immunity; however, little is known about the epigenetic control of natural killer (NK) cell development. Here, we found that NK cell development is severely impaired in mice deficient in the histone H2A deubiquitinase MYSM1. We demonstrated that MYSM1 is required for NK cell maturation but not for NK lineage specification and commitment. We also found that MYSM1 intrinsically controls this NK cell maturation. Mechanistic studies revealed that the expression of transcription factor, inhibitor of DNA-binding protein (ID2), a critical factor for NK cell development, is impaired in Mysm1(-/-) NK cells. MYSM1 interacts with nuclear factor IL-3 (NFIL3, also known as E4BP4), a critical factor for mouse NK cell development, and the recruitment of nuclear factor Il-3 to the ID2 locus is dependent on MYSM1. Further, we observed that MYSM1 is involved in maintaining an active chromatin at the ID2 locus to promote NK cell development. Hence this study demonstrates the critical epigenetic regulation of NK cell development by the histone H2A deubiquitinase MYSM1 through the transcriptional control of transcription factors important for NK cell development.

Indexed as

Adaptive ImmunityAnimalsChromatin ImmunoprecipitationEndopeptidasesEpigenesis, GeneticFlow CytometryHEK293 CellsHumansImmunoblottingInhibitor of Differentiation Protein 2Interleukin-3Killer Cells, NaturalMiceMice, KnockoutReal-Time Polymerase Chain ReactionTrans-ActivatorsEndopeptidasesIdb2 protein, mouseInhibitor of Differentiation Protein 2Interleukin-3MYSM1 protein, mouseTrans-ActivatorsUbiquitin-Specific Proteaseshistone deubiquitinationNFIL3

Identifiers

PMID24062447
PMCPMC3799335
OpenAlexW2059233607

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.