ArticleProceedings of the National Academy of Sciences of the United States of America2013
Basal variability in CREB phosphorylation predicts trait-like differences in amygdala-dependent memory.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
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- Mouse Model of Weak Depression Exhibiting Suppressed cAMP Signaling in the Amygdala, Lower Lipid Catabolism in Liver, and Correlated Gut Microbiota.Frontiers in behavioral neuroscience · 2022Article
- Individual-specific functional connectivity of the amygdala: A substrate for precision psychiatry.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Piperlongumine decreases cognitive impairment and improves hippocampal function in aged mice.International journal of molecular medicine · 2018Article
- CREB, cellular excitability, and cognition: Implications for aging.Behavioural brain research · 2017Review
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- 2-arachidonoylglycerol signaling impairs short-term fear extinction.Translational psychiatry · 2016Article
- Arc expression identifies the lateral amygdala fear memory trace.Molecular psychiatry · 2016Article
- Maintenance of aversive memories shown by fear extinction-impaired phenotypes is associated with increased activity in the amygdaloid-prefrontal circuit.Scientific reports · 2016Article
- Inverse Relationship between Basal Pacemaker Neuron Activity and Aversive Long-Term Memory Formation inFrontiers in cellular neuroscience · 2016Article
- Optogenetic Inhibitor of the Transcription Factor CREB.Chemistry & biology · 2015Article
- Manipulating a "cocaine engram" in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
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- Heterogeneity in signaled active avoidance learning: substantive and methodological relevance of diversity in instrumental defensive responses to threat cues.Frontiers in systems neuroscience · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Much of what is known about the neurobiology of learning and memory comes from studies of the average behavior. In contrast, intersubject differences that emerge within groups are difficult to study systematically and are often excluded from scientific discussion. Nevertheless, population-wide variability is a virtually universal feature of both complex traits, such as intelligence, and hardwired responses, such as defensive behaviors. Here, we use outbred rats to investigate if cAMP response element-binding protein (CREB), a transcription factor that has long been known in experimental settings to be crucial for associative plasticity, participates in natural memory phenotypes. Using a combination of behavioral, biochemical, and viral techniques, we show that a subset of rats with trait-like deficits in aversive memory have basally reduced CREB activity in the lateral amygdala but can be induced to perform at average levels by directly or indirectly enhancing pretraining CREB phosphorylation. These data suggest that endogenous CREB activity in the amygdala may set a critical threshold for plasticity during memory formation.
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Registered trials
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