Trial reportProceedings of the National Academy of Sciences of the United States of America2013
Childhood abuse, parental warmth, and adult multisystem biological risk in the Coronary Artery Risk Development in Young Adults study.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 108 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
RCT of FIND Video Coaching Intervention for Caregivers Facing Economic Adversity
A Scaleable Video Coaching Intervention for Opioid-using Mothers
Who cites it
108 citing papers in PubMed, 3 syntheses or guidelines pooled it, 232 citations in OpenAlex.
- The intergenerational effects of low parental socio-economic position on cardiometabolic and inflammatory outcomes: A systematic review and meta-analysis.European journal of clinical investigation · 2026Pooled it
- The Link Between Positive and Negative Parenting Behaviors and Child Inflammation: A Systematic Review.Child psychiatry and human development · 2023Pooled it
- Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-α.Molecular psychiatry · 2016Pooled it
- Unsupportive parenting moderates the effects of family psychosocial intervention on metabolic syndrome in African American youth.International journal of obesity (2005) · 2018Trial
- Improved sleep quality in older adults with insomnia reduces biomarkers of disease risk: pilot results from a randomized controlled comparative efficacy trial.Psychoneuroendocrinology · 2015Trial
- Associations between childhood maltreatment and mid-life health risks and risky health behaviors in a nationally representative sample.SSM. Mental health · 2026Article
- Associations Between Childhood Adversity and Pain in Breast Cancer Survivors.Biopsychosocial science and medicine · 2026Article
- Early-life determinants of cardiometabolic outcomes and accelerated biological ageing in Colombia.Aging · 2026Article
- Ambivalent self-concept and feared self mediates the relationship between negative early life experiences and obsessive-compulsive symptoms.Scientific reports · 2026Article
- Early life adversity and physical health implications in adulthood: The Multi-Ethnic Study of Atherosclerosis.Psychoneuroendocrinology · 2026Article
- A lifespan approach to biological aging: Early adversity, past-year trauma, and telomere length in women.Psychoneuroendocrinology · 2025Article
- Early Parenting Effects on Childhood Delay of Gratification and Adolescent Allostatic Load.Children (Basel, Switzerland) · 2025Article
- Lifetime chronic stress exposures, stress hormones, and biological aging: Results from the Midlife in the United States (MIDUS) study.Brain, behavior, and immunity · 2025Article
- Home-ics: how experiences of the home impact biology and child neurodevelopmental outcomes.Pediatric research · 2024Review
- Nutritional Modulation of the Gut-Brain Axis: A Comprehensive Review of Dietary Interventions in Depression and Anxiety Management.Metabolites · 2024Review
- The association between adverse childhood experiences and adult cardiac function in the UK Biobank.European heart journal. Imaging methods and practice · 2024Article
- Relationships between childhood adversity and inflammatory biomarkers in adulthood: A cross-sectional analysis of a middle-to older-aged population.SSM - population health · 2024Article
- Neighborhood Disadvantage and Parenting in Early Adolescence Predict Epigenetic Aging and Mortality Risk in Adulthood.Journal of youth and adolescence · 2024Article
- Time-lagged associations between two adverse childhood experiences and later-life cognitive function through educational attainment and stroke.Journal of the International Neuropsychological Society : JINS · 2024Article
- Evidence for the Association Between Adverse Childhood Family Environment, Child Abuse, and Caregiver Warmth and Cardiovascular Health Across the Lifespan: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.Circulation. Cardiovascular quality and outcomes · 2024Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Childhood abuse increases adult risk for morbidity and mortality. Less clear is how this "toxic" stress becomes embedded to influence health decades later, and whether protective factors guard against these effects. Early biological embedding is hypothesized to occur through programming of the neural circuitry that influences physiological response patterns to subsequent stress, causing wear and tear across multiple regulatory systems. To examine this hypothesis, we related reports of childhood abuse to a comprehensive 18-biomarker measure of multisystem risk and also examined whether presence of a loving parental figure buffers against the impact of childhood abuse on adult risk. A total of 756 subjects (45.8% white, 42.7% male) participated in this ancillary substudy of the Coronary Artery Risk Development in Young Adults Study. Childhood stress was determined by using the Risky Families Questionnaire, a well-validated retrospective self-report scale. Linear regression models adjusting for age, sex, race, parental education, and oral contraceptive use found a significant positive relationship between reports of childhood abuse and multisystem health risks [B (SE) = 0.68 (0.16); P < 0.001]. Inversely, higher amounts of reported parental warmth and affection during childhood was associated with lower multisystem health risks [B (SE) = -0.40 (0.14); P < 0.005]. A significant interaction of abuse and warmth (P < 0.05) was found, such that individuals reporting low levels of love and affection and high levels of abuse in childhood had the highest multisystem risk in adulthood.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.