Evidence map›Paper›PMID 24062405›Full record

ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2013

Marital status and survival in patients with cancer.

Ayal A Aizer, Ming-Hui Chen, Ellen P McCarthy, Mallika L Mendu, Sophia Koo, Tyler J Wilhite, Powell L Graham, Toni K Choueiri, Karen E Hoffman, Neil E Martin and 2 more

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In one paragraph

Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 581 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
581citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

581 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  6. Sexual Dysfunction in Women with Cancer: A Systematic Review of Longitudinal Studies.International journal of environmental research and public health · 2022
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521 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Ayal A AizerAyal A. Aizer, Harvard Radiation Oncology Program; Ellen P. McCarthy, Beth Israel Deaconess Medical Center; Mallika L. Mendu, Sophia Koo, Powell L. Graham, Neil E. Martin, and Paul L. Nguyen, Dana-Farber/Brigham and Women's Cancer Center; Tyler J. Wilhite, Harvard Medical School, Boston, MA; Ming-Hui Chen, University of Connecticut, Storrs, CT; Karen E. Hoffman, The University of Texas MD Anderson Cancer Center, Houston, TX; and Jim C. Hu, University of California at Los Angeles, Los Angeles, CA.
Ming-Hui Chen
Ellen P McCarthy
Mallika L Mendu
Sophia Koo
Tyler J Wilhite
Powell L Graham
Toni K Choueiri
Karen E Hoffman
Neil E Martin
Jim C Hu
Paul L Nguyen

Funding

Breath Volatile Metabolites for the Diagnosis of Emerging Invasive Mold InfectionK23AI097225 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI KOO, SOPHIA · 2012 to 2016
$685k
NIAID NIH HHS K23 AI097225
6 · The paper itself

Abstract

purposeTo examine the impact of marital status on stage at diagnosis, use of definitive therapy, and cancer-specific mortality among each of the 10 leading causes of cancer-related death in the United States.

methodsWe used the Surveillance, Epidemiology and End Results program to identify 1,260,898 patients diagnosed in 2004 through 2008 with lung, colorectal, breast, pancreatic, prostate, liver/intrahepatic bile duct, non-Hodgkin lymphoma, head/neck, ovarian, or esophageal cancer. We used multivariable logistic and Cox regression to analyze the 734,889 patients who had clinical and follow-up information available.

resultsMarried patients were less likely to present with metastatic disease (adjusted odds ratio [OR], 0.83; 95% CI, 0.82 to 0.84; P < .001), more likely to receive definitive therapy (adjusted OR, 1.53; 95% CI, 1.51 to 1.56; P < .001), and less likely to die as a result of their cancer after adjusting for demographics, stage, and treatment (adjusted hazard ratio, 0.80; 95% CI, 0.79 to 0.81; P < .001) than unmarried patients. These associations remained significant when each individual cancer was analyzed (P < .05 for all end points for each malignancy). The benefit associated with marriage was greater in males than females for all outcome measures analyzed (P < .001 in all cases). For prostate, breast, colorectal, esophageal, and head/neck cancers, the survival benefit associated with marriage was larger than the published survival benefit of chemotherapy.

conclusionEven after adjusting for known confounders, unmarried patients are at significantly higher risk of presentation with metastatic cancer, undertreatment, and death resulting from their cancer. This study highlights the potentially significant impact that social support can have on cancer detection, treatment, and survival.

Indexed as

Marital StatusAgedFemaleHumansMaleMiddle AgedNeoplasmsOdds RatioProportional Hazards ModelsSEER ProgramSocial SupportUnited States

Identifiers

PMID24062405
PMCPMC4878087

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.