Observational studyEuropean journal of endocrinology2013
Irisin mRNA and circulating levels in relation to other myokines in healthy and morbidly obese humans.
Observational study in European journal of endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01986530 (Circulating Irisin in Healthy Young Men and Women and Correlation With Lean Body Mass, Fat Mass and Adipocytokines. Circadian and Seasonal Variation and the Effect of Food Intake and Exercise), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Circulating Irisin in Healthy Young Men and Women and Correlation With Lean Body Mass, Fat Mass and Adipocytokines. Circadian and Seasonal Variation and the Effect of Food Intake and Exercise
Who cites it
23 citing papers in PubMed, 62 citations in OpenAlex.
- Effects of elastic band resistance training and nutritional supplementation on muscle quality and circulating muscle growth and degradation factors of institutionalized elderly women: the Vienna Active Ageing Study (VAAS).European journal of applied physiology · 2016Trial
- Circulating irisin, omentin-1, and lipoprotein subparticles in adults at higher cardiovascular risk.Metabolism: clinical and experimental · 2014Trial
- FNDC4 and FNDC5 Attenuate SARS-CoV-2 S1-Induced Inflammatory Responses in Human Adipose Tissue.European journal of clinical investigation · 2026Article
- Irisin and Cardiometabolic Disorders in Obesity: A Systematic Review.International journal of inflammation · 2023Review
- Effects of functional training with blood occlusion on the irisin, follistatin, and myostatin myokines in elderly men.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2022Article
- Irisin reduces inflammatory signaling pathways in inflammation-mediated metabolic syndrome.Molecular and cellular endocrinology · 2022Review
- Interindividual Variation in Cardiorespiratory Fitness: A Candidate Gene Study in Han Chinese People.Genes · 2020Article
- Irisin promotes cardiac progenitor cell-induced myocardial repair and functional improvement in infarcted heart.Journal of cellular physiology · 2019Article
- Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases.Diabetes, metabolic syndrome and obesity : targets and therapy · 2018Article
- Association of serum irisin concentrations with the presence and severity of obstructive sleep apnea syndrome.Journal of clinical laboratory analysis · 2017Article
- Increased FNDC5 is associated with insulin resistance in high fat-fed mice.Physiological reports · 2017Article
- Serum Irisin Level Can Predict the Severity of Coronary Artery Disease in Patients with Stable Angina.Korean circulation journal · 2017Article
- Activin A and follistatin in patients with nonalcoholic fatty liver disease.Metabolism: clinical and experimental · 2016Article
- Loss of muscle mass: current developments in cachexia and sarcopenia focused on biomarkers and treatment.Journal of cachexia, sarcopenia and muscle · 2015Review
- Irisin, a Novel Myokine, Regulates Glucose Uptake in Skeletal Muscle Cells via AMPK.Molecular endocrinology (Baltimore, Md.) · 2015Article
- Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in mice.International journal of obesity (2005) · 2015Article
- Fibronectin type III domain containing 5 expression in skeletal muscle in chronic heart failure-relevance of inflammatory cytokines.Journal of cachexia, sarcopenia and muscle · 2015Article
- Circulating irisin levels and coronary heart disease: association with future acute coronary syndrome and major adverse cardiovascular events.International journal of obesity (2005) · 2015Article
- Irisin ERKs the fat.Diabetes · 2014Article
- FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs.Age (Dordrecht, Netherlands) · 2014Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveSkeletal muscle is considered to be an endocrine organ that secretes a number of myokines including follistatin (FST), myostatin (MSTN), activin A, and the newly identified irisin. Irisin's biology and function exhibit similarities with the functions of the FST-MSTN-activin A axis. It remains unknown whether there is any interplay among these molecules. The aim of this study is to examine potential associations of irisin with the FST, MSTN, and activin A axis.
methodsTwo observational studies were performed to evaluate the associations of irisin with the other three peptides. Study A included 150 healthy males aged 18.48±0.16 years with BMI 23.18±3.75 kg/m(2). Fasting serum samples were used to measure the levels of the molecules of interest. Study B included 14 morbidly obese individuals, candidates for bariatric surgery, aged 53.14±8.93 years with BMI 50.18±10.63 kg/m(2). Blood samples were obtained after an overnight fast. Eight out of the 14 participants consented to an optional thigh biopsy during their bariatric surgery. Using the above blood and tissue samples, we measured circulating levels and muscle mRNA of irisin, FST, MSTN, and activin A.
resultsWe report that FNDC5 mRNA in muscle is positively correlated with FST mRNA expression in morbidly obese subjects (ρ=0.93, P<0.001). We also found that circulating irisin is positively correlated with FST circulating levels among lean subjects (ρ=0.17, P=0.05) while this association was suggestive among the obese (ρ=0.56, P=0.07).
conclusionThe newly identified myokine irisin may be positively associated with FST at both the mRNA and circulating protein level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.