ArticleMedical oncology (Northwood, London, England)2013
Histo-biological comparative analysis of bilateral breast cancer.
Article in Medical oncology (Northwood, London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- A comparative clinicopathological and survival analysis of synchronous bilateral breast cancers.Histology and histopathology · 2022Article
- Clinical characteristics and the associated risk factors of the development of bilateral breast cancers: A case-control study.Annals of medicine and surgery (2012) · 2020Article
- Application of MRI Radiomics-Based Machine Learning Model to Improve Contralateral BI-RADS 4 Lesion Assessment.Frontiers in oncology · 2020Article
- Challenges of treating incidental synchronous bilateral breast cancer with differing tumour biology.BMJ case reports · 2016Article
- Comparative genomic analysis reveals bilateral breast cancers are genetically independent.Oncotarget · 2015Article
- Breast-Conserving Surgery in Bilateral Breast Cancer.Annals of surgical oncology · 2015Article
- Synchronous Bilateral Breast Cancers.Journal of clinical and diagnostic research : JCDR · 2015Article
Corrections and comments
- Erratum issuedSughayyer, Maher [corrected to Sughayer, Maher]
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bilateral breast cancer occurs in approximately 7% of surviving breast cancer patients. However, a dilemma exists concerning the notion of whether this represents a de novo second primary tumor versus a breast metastasis. We analyzed 81 patients with bilateral breast cancer, 47 (58%) synchronous tumors and 34 (42%) metachronous tumors. Additionally, charts were reviewed for age, family history, full histology data and biological receptors. We found there were no significant differences in concordance between the first and second primary tumors (in both synchronous and metachronous bilateral breast cancer) with respect to histology; grade; T-category; N-category; ER, PR and HER-2 status. In addition, there was no significant difference in the strength of correlation between ER and PR in the first and secondary primary tumors. Our findings suggest that the differentiation of the origin of contralateral breast cancer based on routine histological and biological concordance is inconclusive. Furthermore, the dilemma will continue to exist until additional molecular approaches are applied routinely for research purposes to resolve the debate.
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Registered trials
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