ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2013
Neurosyphilis manifesting with rapidly progressive dementia: report of three cases.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Association between spirochaetal infection and neurodegenerative diseases: a systematic review and quantitative synthesis of observational studies.Journal of medical microbiology · 2026Pooled it
- Contribution of CNS and extra-CNS infections to neurodegeneration: a narrative review.Journal of neuroinflammation · 2024Review
- Improving Early Recognition of Treatment-Responsive Causes of Rapidly Progressive Dementia: The STAMAnnals of neurology · 2024Observational
- A Narrative Review of the Many Psychiatric Manifestations of Neurosyphilis: The Great Imitator.Cureus · 2023Review
- Neurosyphilis Initially Misdiagnosed as Behavioral Variant Frontotemporal Dementia: Life-Changing Differential Diagnosis.Journal of Alzheimer's disease reports · 2023Article
- Comparison of the clinical efficacy of penicillin and ceftriaxone sodium in the treatment of neurosyphilis with psychiatric symptoms.World journal of psychiatry and mental health research · 2022Article
- Regional Cerebral Blood Flow Abnormalities in Neurosyphilis: A Pilot SPECT Study.Frontiers in neurology · 2021Article
- Neuroimaging Features, Follow-Up Analyses, and Comparisons Between Asymptomatic and Symptomatic Neurosyphilis.Dermatology and therapy · 2020Article
- Neurosyphilis Mimicking Creutzfeldt-Jakob Disease.Dementia and neurocognitive disorders · 2016Article
- Clinical and neuropsychological characteristics of general paresis misdiagnosed as primary psychiatric disease.BMC psychiatry · 2016Article
- Neurosyphilis Update: Atypical is the New Typical.Current infectious disease reports · 2015Article
- Alterations of cognitive function and hippocampal metabolism in asymptomatic neurosyphilis patients: based onFrontiers in neurologyArticle
- A historic case of relapsing-remitting Alzheimer's disease in an adolescent attributed to scarlet fever.Journal of Alzheimer's disease reportsArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurosyphilis is rather an unusual cause of dementia characterized by a rapidly progressive course and psychiatric symptoms. Diagnosis of neurosyphilis should be suspected in the presence of a global cognitive impairment consisting in disorientation, amnesia and severe impairment of speech and judgement and psychiatric symptoms such as depression, mania and psychosis, with a subacute onset. More commonly, clinical manifestations of neurosyphilis include general PARESIS (involvement of Personality, Affect, Reflexes, Eye, Sensorium, Intellect and Speech). Upon clinical suspicion, diagnosis of neurosyphilis is confirmed by a reactive cerebrospinal fluid (CSF)-Venereal Disease Research Laboratory. Here we report three Human Immunodeficiency Virus (HIV)-negative male patients presenting with psychiatric symptoms and a rapidly evolving dementia. Although magnetic resonance imaging did not address to diagnosis, CSF examination was mandatory in neurosyphilis diagnosis. Other diagnostic tools such as neuropsychology and single-photon emission computed tomography resulted supportive in the diagnosis. We showed that a prompt antibiotic treatment might stop disease progression. Therefore, neurosyphilis should be always considered even in HIV-negative patients in the presence of unexpected psychiatric symptoms accompanied by a rapidly evolving cognitive decline.
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