ArticleMethods in molecular biology (Clifton, N.J.)2014
Using the COREX/BEST server to model the native-state ensemble.
Article in Methods in molecular biology (Clifton, N.J.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Loop engineering of enzymes to control their immobilization and ultimately fabricate more efficient heterogeneous biocatalysts.Protein science : a publication of the Protein Society · 2025Article
- Article
- Region-Directed Enzyme Immobilization through Engineering Protein Surface with Histidine Clusters.ACS applied materials & interfaces · 2024Article
- The Serpin-like Loop Insertion of Ovalbumin Increases the Stability and Decreases the OVA 323-339 Epitope Processing Efficiency.Biochemistry · 2021Article
- Deimmunizing substitutions inThe Journal of biological chemistry · 2019Article
- New Insights into Active Site Conformation Dynamics of E. coli PNP Revealed by Combined H/D Exchange Approach and Molecular Dynamics Simulations.Journal of the American Society for Mass Spectrometry · 2016Article
- Terahertz optical measurements of correlated motions with possible allosteric function.Biophysical reviews · 2015Review
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Abstract
Protein structures under normal conditions exist as ensembles of interconverting, transient microstates. A computer algorithm known as COREX/BEST (Biology using Ensemble-based Structural Thermodynamics) was developed to model microstate structures and describe the native ensembles of proteins in statistical thermodynamic terms. This algorithm has been tested extensively and validated through experimental comparisons examining a range of biophysical and functional phenomena, such as structural cooperativity, pH-dependent stability, and cold denaturation. Here, we describe a Web-based implementation of the COREX/BEST algorithm, called the COREX/BEST Server, and demonstrate how to use this online resource to characterize the structural and thermodynamic properties of the native protein ensemble.
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