ArticleClinical oral investigations2014
Effect of a sugar-free pediatric antibiotic on primary tooth enamel hardness when exposed to different sucrose exposure conditions in situ.
Article in Clinical oral investigations, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 7 citations in OpenAlex.
- Inhibition ofJournal of dental sciences · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis in situ study aimed to investigate the effect of a sugar-free antibiotic suspension containing amoxicillin and clavulanic acid on enamel hardness of human primary teeth simulating different conditions of cariogenic challenge. MATERIALS AND
methodsA crossover, partially double-blind study was conducted in three phases of 14 days each, during which 11 volunteers wore palatal devices containing six dental enamel blocks covered with plastic meshes to allow biofilm formation. Dental blocks were extraorally submitted to treatment with a 20 % sucrose solution at three different daily frequencies of exposure (0, 3, and 8 times/day), and to the antibiotic suspension or its excipients at an 8-h time interval application regimen. On the 14th day of each phase, the blocks were removed for enamel analysis (surface and cross-sectional microhardness--SMH and CSMH).
resultsThe antibiotic suspension showed significant higher SMH and CSMH values than the excipients (p < 0.05; Wilcoxon), regardless of the frequency of sucrose exposure. Sucrose exposure did not account for further enamel demineralization both for antibiotic and excipients (p > 0.05; Friedman).
conclusionsA protective effect of the antibiotic suspension on enamel demineralization was verified because its excipients alone promoted more pronounced surface and subsurface enamel demineralization, even in the absence of sucrose exposure. CLINICAL RELEVANCE: The use of a sugar-free amoxicillin/clavulanic acid suspension may promote a protective effect on primary enamel demineralization probably due to its topical effect on dental biofilm.
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