ReviewJournal of industrial microbiology & biotechnology2014
Evolutionary concepts in natural products discovery: what actinomycetes have taught us.
Review in Journal of industrial microbiology & biotechnology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Evaluation of BOX-PCR and REP-PCR as Molecular Typing Tools for Antarctic Streptomyces.Current microbiology · 2020Article
- The In Silico Characterization of a Salicylic Acid Analogue Coding Gene Clusters in SelectedIranian journal of biotechnology · 2019Article
- Brocaeloid D, a novel compound isolated from a wheat pathogenic fungus,Synthetic and systems biotechnology · 2019Article
- Isolation and identification of two alkaloid structures with radical scavenging activity from Actinokineospora sp. UTMC 968, a new promising source of alkaloid compounds.Molecular biology reports · 2018Article
- SANDPUMA: ensemble predictions of nonribosomal peptide chemistry reveal biosynthetic diversity across Actinobacteria.Bioinformatics (Oxford, England) · 2017Article
- Microindolinone A, a Novel 4,5,6,7-Tetrahydroindole, from the Deep-Sea-Derived Actinomycete Microbacterium sp. MCCC 1A11207.Marine drugs · 2017Article
- Molecular beacons to identify gifted microbes for genome mining.The Journal of antibiotics · 2017Article
- Phylogeny-guided (meta)genome mining approach for the targeted discovery of new microbial natural products.Journal of industrial microbiology & biotechnology · 2017Review
- The Orphan Response Regulator Aor1 Is a New Relevant Piece in the Complex Puzzle ofFrontiers in microbiology · 2017Article
- Phylogenomic Analysis of Natural Products Biosynthetic Gene Clusters Allows Discovery of Arseno-Organic Metabolites in Model Streptomycetes.Genome biology and evolution · 2016Article
- Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination.Journal of the American Chemical Society · 2015Article
- The Origin and Evolution of Baeyer-Villiger Monooxygenases (BVMOs): An Ancestral Family of Flavin Monooxygenases.PloS one · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Actinomycetes are a very important source of natural products for the pharmaceutical industry and other applications. Most of the strains belong to Streptomyces or related genera, partly because they are particularly amenable to growth in the laboratory and industrial fermenters. It is unlikely that chemical synthesis can fulfil the needs of the pharmaceutical industry for novel compounds so there is a continuing need to find novel natural products. An evolutionary perspective can help this process in several ways. Genome mining attempts to identify secondary metabolite biosynthetic clusters in DNA sequences, which are likely to produce interesting chemical entities. There are often technical problems in assembling the DNA sequences of large modular clusters in genome and metagenome projects, which can be overcome partially using information about the evolution of the domain sequences. Understanding the evolutionary mechanisms of modular clusters should allow simulation of evolutionary pathways in the laboratory to generate novel compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.