ReviewMolecular systems biology2013
Biomedically relevant circuit-design strategies in mammalian synthetic biology.
Review in Molecular systems biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 58 citations in OpenAlex.
- Logic-Gated HSV-TK/GCV Suicide Gene Circuit for Triple-Negative Breast Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mimicking Molecular Pathways in the Design of Smart Hydrogels for the Design of Vascularized Engineered Tissues.International journal of molecular sciences · 2023Review
- An Account of Models of Molecular Circuits for Associative Learning with Reinforcement Effect and Forced Dissociation.Sensors (Basel, Switzerland) · 2022Article
- A synthetic distributed genetic multi-bit counter.iScience · 2021Article
- Gene regulatory networks exhibit several kinds of memory: quantification of memory in biological and random transcriptional networks.iScience · 2021Article
- Engineering of a Promoter Repressed by a Light-Regulated Transcription Factor inBiodesign research · 2021Article
- Angiogenic biomaterials to promote therapeutic regeneration and investigate disease progression.Biomaterials · 2020Review
- Gut Microbiota and the Alteration of Immune Balance in Skin Diseases: From Nutraceuticals to Fecal Transplantation.Open access Macedonian journal of medical sciences · 2019Review
- Genetic circuits to engineer tissues with alternative functions.Journal of biological engineering · 2019Review
- Bottom-up approaches in synthetic biology and biomaterials for tissue engineering applications.Journal of industrial microbiology & biotechnology · 2018Article
- A multi-landing pad DNA integration platform for mammalian cell engineering.Nucleic acids research · 2018Article
- Low Dose Medicine: theoretical background and scientific evidence.Italian journal of pediatrics · 2018Article
- Functional Dynamics Inside Nano- or Microscale Bio-Hybrid Systems.Frontiers in chemistry · 2018Review
- Article
- Near-infrared optogenetic pair for protein regulation and spectral multiplexing.Nature chemical biology · 2017Article
- Self-adjusting synthetic gene circuit for correcting insulin resistance.Nature biomedical engineering · 2017Article
- Cellular heterogeneity mediates inherent sensitivity-specificity tradeoff in cancer targeting by synthetic circuits.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Dynamics of Protein Expression Reveals Primary Targets and Secondary Messengers of Estrogen Receptor Alpha Signaling in MCF-7 Breast Cancer Cells.Molecular & cellular proteomics : MCP · 2016Article
- Spatiotemporal dynamics of distributed synthetic genetic circuits.Physica D. Nonlinear phenomena · 2016Article
- Rethinking risk assessment for emerging technology first-in-human trials.Medicine, health care, and philosophy · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development and progress in synthetic biology has been remarkable. Although still in its infancy, synthetic biology has achieved much during the past decade. Improvements in genetic circuit design have increased the potential for clinical applicability of synthetic biology research. What began as simple transcriptional gene switches has rapidly developed into a variety of complex regulatory circuits based on the transcriptional, translational and post-translational regulation. Instead of compounds with potential pharmacologic side effects, the inducer molecules now used are metabolites of the human body and even members of native cell signaling pathways. In this review, we address recent progress in mammalian synthetic biology circuit design and focus on how novel designs push synthetic biology toward clinical implementation. Groundbreaking research on the implementation of optogenetics and intercellular communications is addressed, as particularly optogenetics provides unprecedented opportunities for clinical application. Along with an increase in synthetic network complexity, multicellular systems are now being used to provide a platform for next-generation circuit design.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.