ReviewNature reviews. Urology2013
Transperineal biopsy of the prostate--is this the future?
Review in Nature reviews. Urology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02756975 (Prostate Core Needle Biopsy), which is not on this map. Cited by 66 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prostate Core Needle Biopsy
Who cites it
66 citing papers in PubMed, 2 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- Comparison between transrectal and transperineal prostate biopsy for detection of prostate cancer: a meta-analysis and trial sequential analysis.Oncotarget · 2017Pooled it
- Prevention of sepsis prior to prostate biopsy.Investigative and clinical urology · 2016Pooled it
- Developing a five-step training model for transperineal prostate biopsies in a naïve residents' group: a prospective observational randomised study of two different techniques.World journal of urology · 2019Trial
- Comparison between Ultrasound Guided Transperineal and Transrectal Prostate Biopsy: A Prospective, Randomized, and Controlled Trial.Scientific reports · 2015Trial
- Transperineal (TP) Versus Transrectal (TR) Prostate Biopsy: Efficacy, Safety, and Systemic Challenges-A Narrative Review.Journal of clinical medicine · 2026Review
- Histone lactatation-related genes GPR19 and SLC22A16 are important diagnostic markers and drug treatment targets for prostate cancer.Genes & genomics · 2026Article
- The Influence of Music on Perceived Pain and Levels of Anxiety While Undergoing Transperineal Prostate Biopsy: The VIVALDI Trial.European urology open science · 2026Article
- Article
- Article
- Transperineal versus transrectal magnetic resonance imaging-fusion ultrasound-guided prostate biopsy: a comparative analysis of cancer detection in patients with prior negative transrectal ultrasound scan biopsy.Prostate international · 2026Article
- Micro-ultrasound transperineal prostate biopsy as an alternative to MRI-US fusion transrectal biopsy.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2026Article
- Single-Center Comparative Evaluation of Freehand Transperineal and Transrectal Prostate Biopsy Techniques Performed Under Local Anesthesia.Diagnostics (Basel, Switzerland) · 2025Article
- Epidemiology, diagnosis and treatment of anterior prostate cancer.Nature reviews. Urology · 2025Review
- Review
- Choosing the path: insights into transperinealTranslational andrology and urology · 2025Article
- Article
- Development and External Validation of a Nomogram for Predicting Pain Risk Post-Transperineal Prostate Biopsy Using Multi-Parameter Analysis.Journal of pain research · 2025Article
- Cost-effectiveness analysis of different anesthesia strategies for transperineal MRI/US fusion prostate biopsy.Asian journal of andrology · 2024Article
- Incidence of Infection Following Local Anesthetic Transperineal Prostate Biopsy: A Single-Centre Experience.Cureus · 2024Article
- Clinical utility of transperineal template-guided mapping prostate biopsy in a selection of patients under active surveillance and confirmation of patients with negative biopsy for prostate cancer.Frontiers in oncology · 2024Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transperineal prostate biopsy is re-emerging after decades of being an underused alternative to transrectal biopsy guided by transrectal ultrasonography (TRUS). Factors driving this change include possible improved cancer detection rates, improved sampling of the anteroapical regions of the prostate, a reduced risk of false negative results and a reduced risk of underestimating disease volume and grade. The increasing incidence of antimicrobial resistance and patients with diabetes mellitus who are at high risk of sepsis also favours transperineal biopsy as a sterile alternative to standard TRUS-guided biopsy. Factors limiting its use include increased time, training and financial constraints as well as the need for high-grade anaesthesia. Furthermore, the necessary equipment for transperineal biopsy is not widely available. However, the expansion of transperineal biopsy has been propagated by the increase in multiparametric MRI-guided biopsies, which often use the transperineal approach. Used with MRI imaging, transperineal biopsy has led to improvements in cancer detection rates, more-accurate grading of cancer severity and reduced risk of diagnosing clinically insignificant disease. Targeted biopsy under MRI guidance can reduce the number of cores required, reducing the risk of complications from needle biopsy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.