ArticleThe Journal of physiology2013
Glucose utilization rates regulate intake levels of artificial sweeteners.
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
- Metabolic and neural responses to ultraprocessed foods: a randomized, controlled, crossover study.Nature metabolism · 2026Trial
- When does post-ingestive dopamine signaling occur in humans?bioRxiv : the preprint server for biology · 2026Article
- The critical role of gut-brain signalling in eating behaviour and obesity.Nature reviews. Gastroenterology & hepatology · 2026Review
- Linking systemic metabolic state to long-term motor memory: Insights from respiratory exchange ratio and glucose manipulation.The Journal of physiology · 2026Article
- Metrics of glycemic control but not body weight influence flavor nutrient conditioning in humans.Physiology & behavior · 2025Article
- An interoceptive model of energy allostasis linking metabolic and mental health.Science advances · 2025Review
- The interoceptive origin of reinforcement learning.Trends in cognitive sciences · 2025Review
- Obesity impairs brain responses to nutrients.Nature metabolism · 2023Article
- The impact of caloric availability on eating behavior and ultra-processed food reward.Appetite · 2022Article
- The physiological control of eating: signals, neurons, and networks.Physiological reviews · 2022 · on this mapArticle
- Metabolic sensing in AgRP neurons integrates homeostatic state with dopamine signalling in the striatum.eLife · 2022Article
- Reconsolidation of a post-ingestive nutrient memory requires mTOR in the central amygdala.Molecular psychiatry · 2021Article
- Fat and Carbohydrate Interact to Potentiate Food Reward in Healthy Weight but Not in Overweight or Obesity.Nutrients · 2021Observational
- An alternative pathway for sweet sensation: possible mechanisms and physiological relevance.Pflugers Archiv : European journal of physiology · 2020Review
- From biology to behavior: a cross-disciplinary seminar series surrounding added sugar and low-calorie sweetener consumption.Obesity science & practice · 2019Review
- Sugar Metabolism Regulates Flavor Preferences and Portal Glucose Sensing.Frontiers in integrative neuroscience · 2018Article
- Integration of Sweet Taste and Metabolism Determines Carbohydrate Reward.Current biology : CB · 2017Article
- DRD2: Bridging the Genome and Ingestive Behavior.Trends in cognitive sciences · 2017Review
- Rewarding Effects of Operant Dry-Licking Behavior on Neuronal Firing in the Nucleus Accumbens Core.Frontiers in pharmacology · 2017Article
- Circuit organization of sugar reinforcement.Physiology & behavior · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
It is well established that animals including humans attribute greater reinforcing value to glucose-containing sugars compared to their non-caloric counterparts, generally termed 'artificial sweeteners'. However, much remains to be determined regarding the physiological signals and brain systems mediating the attribution of greater reinforcing value to sweet solutions that contain glucose. Here we show that disruption of glucose utilization in mice produces an enduring inhibitory effect on artificial sweetener intake, an effect that did not depend on sweetness perception or aversion. Indeed, such an effect was not observed in mice presented with a less palatable, yet caloric, glucose solution. Consistently, hungry mice shifted their preferences away from artificial sweeteners and in favour of glucose after experiencing glucose in a hungry state. Glucose intake was found to produce significantly greater levels of dopamine efflux compared to artificial sweetener in dorsal striatum, whereas disrupting glucose oxidation suppressed dorsal striatum dopamine efflux. Conversely, inhibiting striatal dopamine receptor signalling during glucose intake in sweet-naïve animals resulted in reduced, artificial sweetener-like intake of glucose during subsequent gluco-deprivation. Our results demonstrate that glucose oxidation controls intake levels of sweet tastants by modulating extracellular dopamine levels in dorsal striatum, and suggest that glucose utilization is one critical physiological signal involved in the control of goal-directed sweetener intake.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.