Evidence map›Paper›PMID 24060881›Full record

ArticleActa biomaterialia2014

A mussel-derived one component adhesive coacervate.

Wei Wei, Yerpeng Tan, Nadine R Martinez Rodriguez, Jing Yu, Jacob N Israelachvili, J Herbert Waite

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biomaterialia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 230 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Condensates as Conformation Editors of Disordered Client Proteins.Journal of the American Chemical Society · 2026
    Article
  5. Recent advances onFundamental research · 2026
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Catechol redox maintenance in mussel adhesion.Nature reviews. Chemistry · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Review

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Wei WeiMaterials Research Laboratory, University of California, Santa Barbara, CA 93106, USA.
Yerpeng TanBiomolecular Science and Engineering Graduate Program, University of California, Santa Barbara, CA 93106, USA.
Nadine R Martinez RodriguezDepartment of Molecular, Cell and Development Biology, University of California, Santa Barbara, CA 93106, USA.
Jing YuDepartment of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA.
Jacob N IsraelachviliMaterials Research Laboratory, University of California, Santa Barbara, CA 93106, USA; Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA. Electronic address: jacob@engineering.ucsb.edu.
J Herbert WaiteMaterials Research Laboratory, University of California, Santa Barbara, CA 93106, USA; Biomolecular Science and Engineering Graduate Program, University of California, Santa Barbara, CA 93106, USA; Department of Molecular, Cell and Development Biology, University of California, Santa Barbara, CA 93106, USA. Electronic address: herbert.waite@lifesci.ucsb.edu.
University of California, Santa Barbara · US

Funding

Translating Mussel AdhesionR01DE018468 · NIDCR · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI WAITE, JOHN HERBERT · 2008 to 2017
$4.2M
NIDCR NIH HHS R01 DE018468
6 · The paper itself

Abstract

Marine organisms process and deliver many of their underwater coatings and adhesives as complex fluids. In marine mussels one such fluid, secreted during the formation of adhesive plaques, consists of a concentrated colloidal suspension of a mussel foot protein (mfp) known as Mfp-3S. The results of this study suggest that Mfp-3S becomes a complex fluid by a liquid-liquid phase separation from equilibrium solution at a pH and ionic strength reminiscent of the conditions created by the mussel foot during plaque formation. The pH dependence of phase separation and its sensitivity indicate that inter-/intra-molecular electrostatic interactions are partially responsible for driving the phase separation. Hydrophobic interactions between the non- polar Mfp-3S proteins provide another important driving force for coacervation. As complex coacervation typically results from charge-charge interactions between polyanions and polycations, Mfp-3S is thus unique in being the only known protein that coacervates with itself. The Mfp-3S coacervate was shown to have an effective interfacial energy of ⩽1mJm(-2), which explains its tendency to spread over or engulf most surfaces. Of particular interest to biomedical applications is the extremely high adsorption capacity of coacervated Mfp-3S on hydroxyapatite.

Indexed as

AdhesivenessAdsorptionAmino Acid SequenceAnimalsBivalviaBuffersDurapatiteHydrogen-Ion ConcentrationMolecular Sequence DataNephelometry and TurbidimetryOsmolar ConcentrationProteinsQuartz Crystal Microbalance TechniquesSpectrum AnalysisTemperatureTime Factorsadhesive protein, musselBuffersDurapatiteProteinsBiological wet adhesionCoacervateHydrophobicityHydroxyapatiteInterfacial energyMussel foot protein

Identifiers

PMID24060881
PMCPMC3960351
OpenAlexW2080186079

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.