ArticleToxicology2013
Evaluation of neurobehavioral and neuroinflammatory end-points in the post-exposure period in rats sub-acutely exposed to manganese.
Article in Toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- The Inflammatory Potential of Dietary Manganese in a Cohort of Elderly Men.Biological trace element research · 2018Trial
- Emergent latent neurotoxic effects of manganese following nominal chronic exposures in human stem cell and Caenorhabditis elegans models.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Frontal-subcortical dysfunction in toxic oil syndrome: a proof-of-concept eye-tracking and cognitive study four decades after exposure.Frontiers in neuroscience · 2025Article
- Article
- Magnetic resonance imaging to assess the brain response to fasting in glioblastoma-bearing rats as a model of cancer anorexia.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023Article
- Methylcyclopentadienyl Manganese Tricarbonyl Alter Behavior and Cause Ultrastructural Changes in the Substantia Nigra of Rats: Comparison with Inorganic Manganese Chloride.Neurochemical research · 2022Article
- Toxic Exposure to Endocrine Disruptors Worsens Parkinson's Disease Progression through NRF2/HO-1 Alteration.Biomedicines · 2022Article
- Atrazine Inhalation Causes Neuroinflammation, Apoptosis and Accelerating Brain Aging.International journal of molecular sciences · 2021Article
- Severity of parkinsonism associated with environmental manganese exposure.Environmental health : a global access science source · 2021Article
- Inflammasomes: An Emerging Mechanism Translating Environmental Toxicant Exposure Into Neuroinflammation in Parkinson's Disease.Toxicological sciences : an official journal of the Society of Toxicology · 2018Review
- Protective effect of vinpocetine against neurotoxicity of manganese in adult male rats.Naunyn-Schmiedeberg's archives of pharmacology · 2018Article
- Occupational Exposure to Manganese and Fine Motor Skills in Elderly Men: Results from the Heinz Nixdorf Recall Study.Annals of work exposures and health · 2017Article
- Coherent and Contradictory Facts, Feats and Fictions Associated with Metal Accumulation in Parkinson's Disease: Epicenter or Outcome, Yet a Demigod Question.Molecular neurobiology · 2017Review
- "Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies".BMC pharmacology & toxicology · 2016Review
- Manganese-induced Neurotoxicity: FromToxicology research · 2015Article
Corrections and comments
- Erratum issuedDinamene, Santos [corrected to Santos, Dinamene]; Camila, Batoreu M [corrected to Batoréu, M Camila]; Luisa, Mateus [corrected to Mateus, M Luísa]; Vanda, Andrade [corrected to Andrade, Vanda]; Ruben, Ramos [corrected to Ramos, Ruben]; Edite, Torres [cor
Authors and funding
18 authors.
Funding
Abstract
Manganese (Mn) can cause manganism, a neurological disorder similar to Parkinson' Disease (PD). The neurobehavioral and neuroinflammatory end-points in the Mn post exposure period have not been studied yet. Rats were injected on alternate days with 8 doses of MnCl2 (25mg/kg) or saline, then euthanized 1, 10, 30 or 70 days following the last dose. Whole-blood (WB) (p<0.05), urine (p<0.05) and brain cortical (p<0.0001) Mn levels were significantly increased 24h after the last dose. Decreases in the rats' ambulation were noted 1, 10 and 30 days after the last Mn dose (p<0.001; p<0.05; p<0.001, respectively) and also in the rearing activity at the four time-points (p<0.05). Cortical glial fibrillary acid protein immunoreactivity (GFAP-ir) was significantly increased at 1, 10, 30 (p<0.0001) and 70 (p<0.001) days after the last Mn dose, as well as tumor necrosis α (TNF-α) levels (p<0.05) but just on day 1. Taken together, the results show that, during the 70-day clearance phase of Mn, the recovery is not immediate as behavioral alterations and neuroinflammation persist long after Mn is cleared from the cortical brain compartment.
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