Evidence map›Paper›PMID 24060391›Full record

ArticleProgress in neuro-psychopharmacology & biological psychiatry2014

Baseline impulsive choice predicts the effects of nicotine and nicotine withdrawal on impulsivity in rats.

Hakan Kayir, Svetlana Semenova, Athina Markou

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Progress in neuro-psychopharmacology & biological psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Exposure to Nicotine Vapor Produced by an Electronic Nicotine Delivery System Causes Short-Term Increases in Impulsive Choice in Adult Male Rats.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022
    Article
  3. Article
  4. Article
  5. Disentangling the effects of cannabis and cigarette smoking on impulsivity.Journal of psychopharmacology (Oxford, England) · 2020
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Withdrawal: Expanding a Key Addiction Construct.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2015
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hakan KayirDepartment of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA, USA; Department of Medical Pharmacology, Psychopharmacology Research Unit, Gulhane Military Medical Academy, Ankara, Turkey.
Svetlana Semenova
Athina Markou
University of California, San Diego · US

Funding

NEUROBIOLOGY OF NICOTINE REWARD AND WITHDRAWALR01DA011946 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MARKOU, ATHINA · 2000 to 2011
$2.4M
Neurobiology of Nicotine Reward and WithdrawalR56DA011946 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MARKOU, ATHINA · 2013 to 2014
$659k
NIDA NIH HHS R01 DA011946NIDA NIH HHS R01DA11946NIDA NIH HHS R56 DA011946
6 · The paper itself

Abstract

Impulsive choice, a form of impulsivity, is associated with tobacco smoking in humans. Trait impulsivity may be a vulnerability factor for smoking, or smoking may lead to impulsive behaviors. We investigated the effects of 14-day nicotine exposure (6.32mg/kg/day base, subcutaneous minipumps) and spontaneous nicotine withdrawal on impulsive choice in low impulsive (LI) and high impulsive (HI) rats. Impulsive choice was measured in the delayed reward task in which rats choose between a small immediate reward and a large delayed reward. HI and LI rats were selected from the highest and lowest quartiles of the group before exposure to nicotine. In non-selected rats, nicotine or nicotine withdrawal had no effect on impulsive choice. In LI rats, chronic nicotine exposure decreased preference for the large reward with larger effects at longer delays, indicating increased impulsive choice. Impulsive choices for the smaller immediate rewards continued to increase during nicotine withdrawal in LI rats. In HI rats, nicotine exposure and nicotine withdrawal had no effect on impulsive choice, although there was a tendency for decreased preference for the large reward at short delays. These results indicate that nicotine- and nicotine withdrawal-induced increases in impulsive choice depend on trait impulsivity with more pronounced increases in impulsive choice in LI compared to HI subjects. Increased impulsivity during nicotine exposure may strengthen the addictive properties of nicotine and contribute to compulsive nicotine use.

Indexed as

Analysis of VarianceAnimalsChoice BehaviorConditioning, OperantDrug Delivery SystemsImpulsive BehaviorMaleNicotinePredictive Value of TestsRatsRats, WistarReinforcement ScheduleRewardSelf AdministrationTime FactorsTobacco Use DisorderNicotineanalysis of varianceANOVAarea under the curveAUCDelay discountingDelayed rewardhHIHigh and low impulsive ratshigh impulsivehour(s)intertrial intervalITILIlow impulsiveminminute(s)ssecond(s)Wistar rats

Identifiers

PMID24060391
PMCPMC3858513
OpenAlexW2116760085

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.