ArticleBMC genetics2013
The sodium channel gene family is specifically expressed in hen uterus and associated with eggshell quality traits.
Article in BMC genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 58 citations in OpenAlex.
- Expression Profile of theVeterinary medicine international · 2026Article
- Dietary sodium sulfate supplementation improves eggshell quality, uterine ion transportation and glycosaminoglycan synthesis in laying hens.Animal bioscience · 2025Article
- N-carbamylglutamate supplementation improves laying performance of layers by regulating hypothalamic-pituitary-ovarian axis.Frontiers in veterinary science · 2025Article
- Descriptive embryological insights of the colorectum of quail embryos with concern to its functional morphology.BMC veterinary research · 2024Article
- Integration of Whole-Genome Resequencing and Transcriptome Sequencing Reveals Candidate Genes in High Glossiness of Eggshell.Animals : an open access journal from MDPI · 2024Article
- Association analysis of production traits of Japanese quail (Coturnix japonica) using restriction-site associated DNA sequencing.Scientific reports · 2023Article
- Inactivation of epithelial sodium ion channel molecules serves as effective diagnostic biomarkers in clear cell renal cell carcinoma.Genes & genomics · 2023Article
- Effects of Growth-Related Genes on Body Measurement Traits in Wenshang Barred Chickens.The journal of poultry science · 2022Article
- H3K27ac chromatin acetylation and gene expression analysis reveal sex- and situs-related differences in developing chicken gonads.Biology of sex differences · 2022Article
- Co-administration of toll-like receptor (TLR)-3 agonist Poly I:C with different infectious bursal disease (IBD) vaccines improves IBD specific immune response in chicken.Veterinary research communications · 2021Article
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- Co-administration of toll-like receptor (TLR)-3 and 4 ligands augments immune response to Newcastle disease virus (NDV) vaccine in chicken.Veterinary research communications · 2019Article
- Immunomodulatory Potential ofVaccines · 2019Article
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- Genetic architecture dissection by genome-wide association analysis reveals avian eggshell ultrastructure traits.Scientific reports · 2016Article
- Endometrial gene expression profile of pregnant sows with extreme phenotypes for reproductive efficiency.Scientific reports · 2015Article
- Genome-wide association study revealed a promising region and candidate genes for eggshell quality in an F2 resource population.BMC genomics · 2015Article
- Integrating transcriptome and genome re-sequencing data to identify key genes and mutations affecting chicken eggshell qualities.PloS one · 2015Article
- The calcified eggshell matrix proteome of a songbird, the zebra finch (Taeniopygia guttata).Proteome science · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEggshell quality is important for the poultry industry. During eggshell formation a mass of inorganic minerals is deposited. The Sodium Channel (SCNN1) gene family plays an essential role in cation transportation. The objective of this study was to investigate the pattern of expression of members of the SCNN1 gene family, their variation and their effects on eggshell quality.
resultThe highest expression of SCNN1a, SCNN1b, and SCNN1g genes were in the active uterus during eggshell mineralization, while SCNN1d showed its highest expression level in the quiescent uterus (no egg present). Nineteen candidate SNPs from the four genes were genotyped in a population of 338 White Leghorn layers. Association analysis between SNPs (haplotypes/diplotypes) and eggshell traits was performed. Among seven significant SNPs, five SNPs were associated with eggshell strength, eggshell thickness, eggshell percentage or/and egg weight, while the other two SNPs within SCNN1d were only associated with eggshell percentage. These SNPs had a 0.25-6.99% contribution to phenotypic variance, depending on the trait. In haplotype analysis, SCNN1b and SCNN1d were associated with egg weight. The SCNN1b and SCNN1g were significantly associated with eggshell weight while only SCNN1g explained 2.04% of phenotypic variance. All the alleles of the members of SCNN1 gene family were associated with eggshell percentage and eggshell thickness, and others members had an association with eggshell strength except for SCNN1a. The contribution of different haplotypes of the SCNN1 gene family to eggshell phenotypic variance ranged from 0.09% to 5.74%.
conclusionsOur study indicated that the SCNN1 gene family showed tissue expression specificity and was significantly associated with eggshell traits in chicken. This study provides evidence that genetic variation in members of the sodium channel can influence eggshell quality.
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