Evidence map›Paper›PMID 24059918›Full record

ReviewFuture microbiology2013

Recent molecular insights into rickettsial pathogenesis and immunity.

Sanjeev K Sahni, Hema P Narra, Abha Sahni, David H Walker

Open access · greenAbstract readReview
In one paragraph

Review in Future microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 107 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. [A case of Guillain-Barré syndrome due to infection withMedecine tropicale et sante internationale · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. ACS infectious diseases · 2022
    Article
  9. Article
  10. Article
  11. Molecular Characterization by Multilocus Sequence Typing and Diversity Analysis ofVector borne and zoonotic diseases (Larchmont, N.Y.) · 2022
    Article
  12. Subversion of host cell signaling: The arsenal of Rickettsial species.Frontiers in cellular and infection microbiology · 2022
    Review
  13. Review
  14. Article
  15. Article
  16. Mediterranean Spotted Fever: Current Knowledge and Recent Advances.Tropical medicine and infectious disease · 2021
    Review
  17. Manipulation of Host Cell Organelles by Intracellular Pathogens.International journal of molecular sciences · 2021
    Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sanjeev K SahniDepartment of Pathology & Institute for Human Infections & Immunity, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA.
Hema P Narra
Abha Sahni
David H Walker
The University of Texas Medical Branch at Galveston · US

Funding

Regulatory Oxygenases in Vasculopathic RickettsiosesR01AI067613 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SAHNI, SANJEEV K. · 2006 to 2010
$1.7M
Host Cell JAK-STAT Activation and Pathogenesis of Spotted Fever RickettsiosesR56AI091777 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SAHNI, SANJEEV K. · 2012 to 2012
$383k
NIAID NIH HHS R01 AI067613NIAID NIH HHS R56 AI091777
6 · The paper itself

Abstract

Human infections with arthropod-borne Rickettsia species remain a major global health issue, causing significant morbidity and mortality. Epidemic typhus due to Rickettsia prowazekii has an established reputation as the 'scourge of armies', and as a major determinant of significant 'historical turning points'. No suitable vaccines for human use are currently available to prevent rickettsial diseases. The unique lifestyle features of rickettsiae include obligate intracellular parasitism, intracytoplasmic niche within the host cell, predilection for infection of microvascular endothelium in mammalian hosts, association with arthropods and the tendency for genomic reduction. The fundamental research in the field of Rickettsiology has witnessed significant recent progress in the areas of pathogen adhesion/invasion and host immune responses, as well as the genomics, proteomics, metabolomics, phylogenetics, motility and molecular manipulation of important rickettsial pathogens. The focus of this review article is to capture a snapshot of the latest developments pertaining to the mechanisms of rickettsial pathogenesis and immunity.

Indexed as

ImmunityAnimalsBacterial ProteinsHost-Pathogen InteractionsHumansRickettsiaRickettsia InfectionsBacterial Proteins

Identifiers

PMID24059918
PMCPMC3923375
OpenAlexW2119021881

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.