ArticleJournal of the American Chemical Society2013
Tunable cytotoxicity of rhodamine 6G via anion variations.
Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Mitochondria-targeted strategies in tumor immunity.Frontiers in immunology · 2025Review
- Potential of a COMaterials today. Bio · 2024Article
- Photophysics of fluorescent nanoparticles based on organic dyes - challenges and design principles.Chemical science · 2024Review
- A COPharmaceutics · 2023Article
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- A Multifunctional Conjugated Polymer Developed as an Efficient System for Differentiation of SH-SY5Y Tumour Cells.Polymers · 2022Article
- Article
- Enhanced photothermal heating and combination therapy of NIR dyeJournal of materials chemistry. B · 2022Article
- Influence of Electroconvection on Chronopotentiograms of an Anion-Exchange Membrane in Solutions of Weak Polybasic Acid Salts.International journal of molecular sciences · 2021Article
- Complementary Nucleobase Interactions Drive Co-Assembly of Drugs and Nanocarriers for Selective Cancer Chemotherapy.Pharmaceutics · 2021Article
- Ionic Liquids Toxicity-Benefits and Threats.International journal of molecular sciences · 2020Review
- Comparison of Chemotherapeutic Activities of Rhodamine-Based GUMBOS and NanoGUMBOS.Molecules (Basel, Switzerland) · 2020Article
- Delivery of Small Molecule EF2 Kinase Inhibitor for Breast and Pancreatic Cancer Cells Using Hyaluronic Acid Based Nanogels.Pharmaceutical research · 2020Article
- Article
- Modulating cellular cytotoxicity and phototoxicity of fluorescent organic salts through counterion pairing.Scientific reports · 2019Article
- Chemical-PDMS binding kinetics and implications for bioavailability in microfluidic devices.Lab on a chip · 2019Article
- Mitochondria targeting IR780-based nanoGUMBOS for enhanced selective toxicity towards cancer cells.RSC advances · 2018Article
- Emissive nanoparticles from pyridinium-substituted tetraphenylethylene salts: imaging and selective cytotoxicity towards cancer cellsChemical science · 2016Article
- Mitochondria-targeted Triphenylamine Derivatives Activatable by Two-Photon Excitation for Triggering and Imaging Cell Apoptosis.Scientific reports · 2016Article
- Recycling antibiotics into GUMBOS: a new combination strategy to combat multi-drug-resistant bacteria.Molecules (Basel, Switzerland) · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Chemotherapeutic agents with low toxicity to normal tissues are a major goal in cancer research. In this regard, the therapeutic activities of cationic dyes, such as rhodamine 6G, toward cancer cells have been studied for decades with observed toxicities toward normal and cancer cells. Herein, we report rhodamine 6G-based organic salts with varying counteranions that are stable under physiological conditions, display excellent fluorescence photostability, and more importantly have tunable chemotherapeutic properties. Our in vitro studies indicate that the hydrophobic compounds of this series allow production of nanoparticles which are nontoxic to normal cells and toxic to cancer cells. Furthermore, the anions, in combination with cations such as sodium, were observed to be nontoxic to both normal and cancer cells. To the best of our knowledge, this is the first demonstration that both the cation and anion play an extremely important and cooperative role in the antitumor properties of these compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.