Evidence map›Paper›PMID 24058900›Full record

ArticleThe journal of allergy and clinical immunology. In practice

Food allergy and increased asthma morbidity in a School-based Inner-City Asthma Study.

James L Friedlander, William J Sheehan, Sachin N Baxi, Lianne S Kopel, Jonathan M Gaffin, Al Ozonoff, Chunxia Fu, Diane R Gold, Wanda Phipatanakul

Open access · bronzeAbstract read
In one paragraph

Article in The journal of allergy and clinical immunology. In practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 78 citations in OpenAlex.

  1. Pooled it
  2. [A Meta analysis of risk factors for asthma in Chinese children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2018
    Pooled it
  3. Pediatric Asthma and Food Allergy.Indian journal of pediatrics · 2017
    Pooled it
  4. Article
  5. Real-world impact of mepolizumab on pediatric and adolescent patients with severe asthma.The journal of allergy and clinical immunology. Global · 2026
    Article
  6. Metabolomic and immunological signatures of asthma severity in children.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Article
  7. Review
  8. Anxiety among youth with food allergy.Journal of pediatric psychology · 2024
    Article
  9. Article
  10. Multifood allergy: More than meets the eye.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2023
    Article
  11. Article
  12. Short-acting βPediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022
    Article
  13. Food Allergies in Inner-City Schools: Addressing Disparities and Improving Management.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022
    Review
  14. Article
  15. Article
  16. Detection of Food Allergens in School and Home Environments of Elementary Students.The journal of allergy and clinical immunology. In practice · 2021
    Article
  17. Article
  18. The effect of a cow's milk-free diet on asthma control in children: a quasi-experimental study.American journal of clinical and experimental immunology · 2021
    Article
  19. Food allergy in at-risk adolescents with asthma: A key area for focus.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

James L Friedlander
William J Sheehan
Sachin N Baxi
Lianne S Kopel
Jonathan M Gaffin
Al Ozonoff
Chunxia Fu
Diane R Gold
Wanda Phipatanakul
Boston Children's Hospital · USBrigham and Women's Hospital · USHarvard University · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
MOLECULAR BASIS OF ALLERGIC AND IMMUNOLOGIC DISEASET32AI007512 · NIAID · CHILDREN'S HOSPITAL BOSTON · PI Janet Chou, Peter A Nigrovic · 1996 to 2026
$13.1M
ALLERGENS IN INNER-CITY SCHOOLS AND CHILDHOOD ASTHMAR01AI073964 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2008 to 2012
$4.6M
Midcareer Investigator Award: Urban School Allergen Exposures and Childhood AsthmK24AI106822 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2013 to 2022
$1.9M
School-based air pollution and asthma morbidity in Inner City School ChildrenK23AI106945 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI GAFFIN, JONATHAN MARK · 2013 to 2017
$822k
NCRR NIH HHS UL1 RR 025758NCRR NIH HHS UL1 RR025758NIAID NIH HHS K23 AI106945NIAID NIH HHS K24 AI 106822NIAID NIH HHS K24 AI106822NIAID NIH HHS R01 AI 073964NIAID NIH HHS R01 AI073964NIAID NIH HHS R01 AI 073964-02S1NIAID NIH HHS T32 AI007512NIAID NIH HHS T32 AI007512-25
6 · The paper itself

Abstract

backgroundChildren with asthma have increased prevalence of food allergies. The relationship between food allergy and asthma morbidity is unclear.

objectiveWe aimed to investigate the presence of food allergy as an independent risk factor for increased asthma morbidity by using the School Inner-City Asthma Study, a prospective study that evaluates risk factors and asthma morbidity among urban children.

methodsWe prospectively surveyed, from inner-city schools, 300 children with physician-diagnosed asthma, followed by clinical evaluation. Food allergies were reported, which included symptoms experienced within 1 hour of food ingestion. Asthma morbidity, pulmonary function, and resource utilization were compared between children with food allergies and those without.

resultsSeventy-three of 300 children with asthma (24%) surveyed had physician-diagnosed food allergy, and 36 (12%) had multiple food allergies. Those with any food allergy independently had increased risk of hospitalization (OR [odds ratio] 2.35 [95% CI, 1.30-4.24]; P = .005) and use of controller medication (OR 1.99 [95% CI, 1.06-3.74]; P = .03). Those with multiple food allergies also had an independently higher risk of hospitalization in the past year (OR 4.10 [95% CI, 1.47-11.45]; P = .007), asthma-related hospitalization (OR 3.52 [95% CI, 1.12-11.03]; P = .03), controller medication use (OR 2.38 [95% CI, 1.00-5.66]; P = .05), and more provider visits (median, 4.5 vs 3.0; P = .008). Furthermore, lung function was significantly lower (percent predicted FEV1 and FEV1/FVC ratios) in both food allergy category groups.

conclusionsFood allergy is highly prevalent in inner-city school-aged children with asthma. Children with food allergies have increased asthma morbidity and health resource utilization with decreased lung function, and this association is stronger in those with multiple food allergies.

Indexed as

AdolescentAsthmaChildChild, PreschoolCitiesFemaleFood HypersensitivityForced Expiratory VolumeHospitalizationHumansMaleMorbidityNew EnglandPrevalenceProspective StudiesRisk Factors

Identifiers

PMID24058900
PMCPMC3777668
OpenAlexW1965738072

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.