ReviewWorm2013
Ancient neuromodulation by vasopressin/oxytocin-related peptides.
Review in Worm, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 84 citations in OpenAlex.
- Decoding Neuropeptide Complexity: Advancing Neurobiological Insights from Invertebrates to Vertebrates through Evolutionary Perspectives.ACS chemical neuroscience · 2025Review
- The Relationship Between Oxytocin and Alcohol Dependence.Current topics in behavioral neurosciences · 2025Review
- Expression patterns and behavioral effects of conopressin and APGWamide in the nudibranch Berghia stephanieae.Peptides · 2024Article
- A cAMP-biosensor-based assay for measuring plasma arginine-vasopressin levels.Scientific reports · 2024Article
- Evolutionary conserved peptide and glycoprotein hormone-like neuroendocrine systems in C. elegans.Molecular and cellular endocrinology · 2024Article
- Natural variation in oxytocin receptor signaling causes widespread changes in brain transcription: a link to the natural killer gene complex.bioRxiv : the preprint server for biology · 2023Article
- A Putative Role of Vasopressin/Oxytocin-Type Neuropeptide in Osmoregulation and Feeding Inhibition ofInternational journal of molecular sciences · 2023Article
- Oxytocin and oxygen: the evolution of a solution to the 'stress of life'.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Parochial cooperation in wild chimpanzees: a model to explain the evolution of parochial altruism.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Oxytocin Involvement in Body Composition Unveils the True Identity of Oxytocin.International journal of molecular sciences · 2021Review
- An oxytocin/vasopressin-related neuropeptide modulates social foraging behavior in the clonal raider ant.PLoS biology · 2021Article
- Identification of Low Molecular Weight Proteins and Peptides fromBiomolecules · 2021Article
- Neuropeptide signalling systems - An underexplored target for venom drug discovery.Biochemical pharmacology · 2020Review
- What is resilience: an affiliative neuroscience approach.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2020Article
- Comparative and Evolutionary Physiology of Vasopressin/ Oxytocin-Type Neuropeptide Signaling in Invertebrates.Frontiers in endocrinology · 2020Review
- LeuScientific reports · 2019Article
- Ancient role of vasopressin/oxytocin-type neuropeptides as regulators of feeding revealed in an echinoderm.BMC biology · 2019Article
- Review
- Neuropeptide precursors and neuropeptides in the sea cucumber Apostichopus japonicus: a genomic, transcriptomic and proteomic analysis.Scientific reports · 2019Article
- Oxytocin structure and function in New World monkeys: from pharmacology to behavior.Integrative zoology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropeptidergic signaling is widely adopted by animals for the regulation of physiology and behavior in a rapidly changing environment. The vasopressin/oxytocin neuropeptide family originates from an ancestral peptide precursor in the antecedent of protostomian and deuterostomian animals. In vertebrates, vasopressin and oxytocin have both hormonal effects on peripheral target tissues, such as in the regulation of reproduction and water balance, and neuromodulatory actions in the central nervous system controlling social behavior and cognition. The recent identification of vasopressin/oxytocin-related signaling in C. elegans reveals that this peptidergic system is widespread among nematodes. Genetic analysis of the C. elegans nematocin system denotes vasopressin/oxytocin-like peptides as ancient neuromodulators of neuronal circuits involved in reproductive behavior and associative learning, whereas former invertebrate studies focused on conserved peripheral actions of this peptide family. Nematocin provides neuromodulatory input into the gustatory plasticity circuit as well as into distinct male mating circuits to generate a coherent mating behavior. Molecular interactions are comparable to those underlying vasopressin- and oxytocin-mediated effects in the mammalian brain. Understanding how the vasopressin/oxytocin family fine-tunes neuronal circuits for social behavior, learning and memory poses a major challenge. Functional conservation of these effects in nematodes and most likely in other invertebrates enables the development of future models to help answering this question.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.