Evidence map›Paper›PMID 24058828›Full record

ArticleWorm2012

Epigenetic memory of longevity in Caenorhabditis elegans.

Bérénice A Benayoun, Anne Brunet

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Worm, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Bérénice A BenayounDepartment of Genetics; Stanford University; Stanford, CA USA.
Anne Brunet
Stanford University · US

Funding

Molecular mechanisms underlying lifespan extension by dietary restrictionR01AG031198 · NIA · STANFORD UNIVERSITY · PI BRUNET, ANNE · 2009 to 2013
$2.0M
Molecular Mechanisms Underlying Lifespan Extension by Environmental StimuliR56AG031198 · NIA · STANFORD UNIVERSITY · PI BRUNET, ANNE · 2015 to 2015
$438k
NIA NIH HHS R01 AG031198NIA NIH HHS R56 AG031198
6 · The paper itself

Abstract

A recent study by Greer et al. in the nematode C. elegans has shown transgenerational epigenetic inheritance of longevity in the descendants of worms deficient for subunits of a complex responsible for histone H3 lysine 4 trimethylation (H3K4me3). In this commentary, we discuss the implications of this epigenetic memory of longevity and the potential mechanisms underlying this phenomenon. The transgenerational inheritance of longevity could result from heritable depletion of H3K4me3 at particular aging-regulating gene loci that would only be progressively replenished. The epigenetic memory of longevity could also be explained by the transgenerational transmission of other molecules, for example other proteins or non-coding RNAs. The discovery of an epigenetic memory of longevity in worms raises the intriguing possibility that environmental cues modulating longevity in ancestors might affect subsequent generations in a non-Mendelian manner. Another remaining intriguing question is whether transgenerational inheritance of longevity also exists in other species, including mammals.

Indexed as

agingepigeneticsH3K4me3longevitytransgenerational inheritance

Identifiers

PMID24058828
PMCPMC3670177
OpenAlexW1970227932

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.