Trial reportPloS one2013
Gallbladder gallstone disease is associated with newly diagnosed coronary artery atherosclerotic disease: a cross-sectional study.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Pooled it
- The Association between Gallstone Disease and Cardiovascular Disease: A Systematic Review and Meta-Analysis.Reviews on recent clinical trials · 2025Pooled it
- Gallstone Disease and the Risk of Cardiovascular Disease.Scientific reports · 2019Pooled it
- Screen-detected gallstone disease and cardiovascular disease.European journal of epidemiology · 2017Trial
- Endothelial cell alterations in capillaries of adipose tissue from patients affected by lipedema.Obesity (Silver Spring, Md.) · 2025Article
- Gallstone disease and the risk of cardiac mortality in patients with acute coronary syndrome.Frontiers in cardiovascular medicine · 2022Article
- The impact of lifestyle stressors, menstrual pattern, and cardiometabolic risk factors on young females with cholelithiasis.Journal of education and health promotion · 2022Article
- Reduced Risk of Atrial Fibrillation Following Cholecystectomy: A Nationwide Population-Based Study.Frontiers in aging neuroscience · 2021Article
- The association between gallstone disease and plaque in the abdominopelvic arteries.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2017Article
- Enzyme pattern of biliary colic: A counterintuitive picture.World journal of hepatology · 2016Article
- Gallstone Disease and the Risk of Ischemic Heart Disease.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Epidemiology, management, and economic evaluation of screening of gallstone disease among type 2 diabetics: A systematic review.World journal of clinical cases · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsThe association between gallstone disease and coronary artery atherosclerotic disease (CAD) remains unclear. To clarify their relationship, patients with CAD newly diagnosed by coronary angiography were investigated in this cross-sectional study.
methodsThe study cohort consisted of 1,270 patients undergoing coronary angiography for the first time between January 2007 and September 2011. Patients with ≥50% diameter stenosis in any major coronary artery on coronary angiography were defined as being CAD positive (n = 766) and those with no stenosis as CAD negative (n = 504). Multivariate logistic regression was used to investigate the relationship between gallstone disease and CAD. The odds ratios (OR) of factors associated with CAD were calculated. In addition, CAD-positive and CAD-negative patients were matched one-to-one by age, gender and metabolic syndrome (MetS), and the association between gallbladder disease and CAD was determined.
resultsThe prevalence of gallstone disease was significantly higher in CAD-positive than in CAD negative patients (149/766 [19.5%] vs 57/504 [11.3%], P<0.01). Gallstone disease was significantly associated with CAD (adjusted OR = 1.59, 95% confidence interval [CI] 1.10-2.31). Following matched pairing of 320 patients per group, gallstone disease remained significantly associated with CAD (adjusted OR = 1.69, 95% CI: 1.08-2.65).
conclusionGallstone disease is strongly associated with CAD diagnosed by coronary angiography.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.