ArticlePloS one2013
Runx1 is critical for PTH-induced onset of mesenchymal progenitor cell chondrogenic differentiation.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- PTH Promotes Chondrogenesis of Fibrocartilage Stem Cells and Alleviates Temporomandibular Joint Osteoarthritis.Tissue engineering and regenerative medicine · 2025Article
- Fracture healing: cellular mechanisms and impact of parathyroid hormone and its analogs.Frontiers in endocrinology · 2025Review
- Review
- New Insights into Calorie Restriction Induced Bone Loss.Endocrinology and metabolism (Seoul, Korea) · 2023Article
- Review
- PTH (1-34) enhances the therapeutic effect of bone marrow mesenchymal stem cell-derived exosomes by inhibiting proinflammatory cytokines expression on OA chondrocyte repair in vitro.Arthritis research & therapy · 2022Article
- Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways.PLoS genetics · 2021Article
- Runt-related transcription factor 1 is required for murine osteoblast differentiation and bone formation.The Journal of biological chemistry · 2020Article
- Role of MicroRNA-141 in the Aging Musculoskeletal System: A Current Overview.Mechanisms of ageing and development · 2019Review
- Effect of the PTHrP(1-34) analog abaloparatide on inducing chondrogenesis involves inhibition of intracellular reactive oxygen species production.Biochemical and biophysical research communications · 2019Article
- Progenitor recruitment and adipogenic lipolysis contribute to the anabolic actions of parathyroid hormone on the skeleton.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Hypophosphatemia Regulates Molecular Mechanisms of Circadian Rhythm.Scientific reports · 2018Article
- Hyperstimulation of CaSR in human MSCs by biomimetic apatite inhibits endochondral ossification via temporal down-regulation of PTH1R.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- LncRNA-HIT Functions as an Epigenetic Regulator of Chondrogenesis through Its Recruitment of p100/CBP Complexes.PLoS genetics · 2015Article
- Notch inhibits chondrogenic differentiation of mesenchymal progenitor cells by targeting Twist1.Molecular and cellular endocrinology · 2015Article
- Parathyroid hormone 1-34 enhances extracellular matrix deposition and organization during flexor tendon repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2015Article
- Deletion of RBPJK in Mesenchymal Stem Cells Enhances Osteogenic Activity by Up-Regulation of BMP Signaling.PloS one · 2015Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Parathyroid hormone (PTH) plays a critical role in the regulation of chondrogenesis. In this study, we have found for the first time that Runt-related transcription factor 1 (Runx1) contributes to PTH-induced chondrogenesis. Upon PTH treatment, limb bud mesenchymal progenitor cells in micromass culture showed an enhanced chondrogenesis, which was associated with a significant increase of chondrogenic marker gene expression, such as type II collagen and type X collagen. Runx1 was also exclusively expressed in cells treated with PTH at the onset stage of chondrogenesis. Knockdown of Runx1 completely blunted PTH-mediated chondrogenesis. Furthermore, PTH induced Runx1 expression and chondrogenesis were markedly reduced by inhibition of protein kinase A (PKA) signaling. Taken together, our present study indicates that chondrogenesis induced by PTH in mesenchymal progenitor cells is mediated by Runx1, which involves the activation of PKA. These data provide a novel insight into understanding the molecular mechanisms behind PTH-enhanced cartilage regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.