Trial reportPloS one2013
PET reveals inflammation around calcified Taenia solium granulomas with perilesional edema.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Diagnosis and Treatment of Neurocysticercosis: 2017 Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Guideline
- Test-retest reproducibility of [(11)C]PBR28 binding to TSPO in healthy control subjects.European journal of nuclear medicine and molecular imaging · 2016Trial
- Refining seizure foci localization: the potential of TSPO-PET.Acta epileptologica · 2025Review
- Calcified Neurocysticercosis: Understanding Dead (Not Necessarily Inactive) Parasites.The American journal of tropical medicine and hygiene · 2025Review
- Epilepsy Due to Solitary Calcified Cysticercus Granuloma.Pathogens (Basel, Switzerland) · 2023Article
- Helminthic dehydrogenase drives PGEEMBO reports · 2022Article
- Epileptogenesis in Common Parasitic Infections.Current neurology and neuroscience reports · 2022Review
- Imaging correlates of serum enzyme-linked immunoelectrotransfer blot (EITB) positivity in patients with parenchymal neurocysticercosis: results from 521 patients.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2022Article
- Have (R)-[European journal of nuclear medicine and molecular imaging · 2021Article
- Unique Characteristics of Epilepsy Development in Neurocysticercosis.The American journal of tropical medicine and hygiene · 2020Review
- Neurocysticercosis and Hippocampal Atrophy: MRI Findings and the Evolution of Viable or Calcified Cysts in Patients With Neurocysticercosis.Frontiers in neurology · 2019Article
- Inflammation is a key risk factor for persistent seizures in neurocysticercosis.Annals of clinical and translational neurology · 2018Article
- Pseudoreference Regions for Glial Imaging withJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018Article
- Natural History of Patients With Perilesional Edema Around Taenia solium Calcified Granulomas.The Journal of infectious diseases · 2017Article
- MicroRNAs inFrontiers in microbiology · 2017Review
- Disease Centered Around Calcified Taenia solium Granuloma.Trends in parasitology · 2017Review
- Update on the Diagnosis and Management of Neurocysticercosis.Current infectious disease reports · 2016Review
- Article
- Update on Cysticercosis Epileptogenesis: the Role of the Hippocampus.Current neurology and neuroscience reports · 2016Review
- Neuroimaging of epilepsy.Handbook of clinical neurology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveNeurocysticercosis, an infection with the larval form of the tapeworm, Taeniasolium, is the cause of 29% of epilepsy in endemic regions. Epilepsy in this population is mostly associated with calcified granulomas; at the time of seizure recurrence 50% of those with calcifications demonstrate transient surrounding perilesional edema. Whether edema is consequence of the seizure, or a result of host inflammation directed against parasite antigens or other processes is unknown. To investigate whether perilesional edema is due to inflammation, we imaged a marker of neuroinflammation, translocater protein (TSPO), using positron emission tomography (PET) and the selective ligand (11)C-PBR28.
methodsIn nine patients with perilesional edema, degenerating cyst or both, PET findings were compared to the corresponding magnetic resonance images. Degenerating cysts were also studied because unlike perilesional edema, degenerating cysts are known to have inflammation. In three of the nine patients, changes in (11)C-PBR28 binding were also studied over time. (11)C-PBR28 binding was compared to the contralateral un-affected region.
results(11)C-PBR28 binding increased by a mean of 13% in perilesional edema or degenerating cysts (P = 0.0005, n = 13 in nine patients). Among these 13 lesions, perilesional edema (n=10) showed a slightly smaller increase of 10% compared to the contralateral side (P = 0.005) than the three degenerating cysts. In five lesions with perilesional edema in which repeated measurements of (11)C-PBR28 binding were done, increased binding lasted for 2-9 months.
conclusionsIncreased TSPO in perilesional edema indicates an inflammatory etiology. The long duration of increased TSPO binding after resolution of the original perilesional edema and the pattern of periodic episodes is consistent with intermittent exacerbation from a continued baseline presence of low level inflammation. Novel anti-inflammatory measures may be useful in the prevention or treatment of seizures in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.