ArticlePloS one2013
Genetic effects on DNA methylation and its potential relevance for obesity in Mexican Americans.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Epigenetics and human obesity.International journal of obesity (2005) · 2015Pooled it
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- The Transcription FactorCells · 2023Review
- Epigenetic Dysregulation of theCells · 2022Article
- Association of Promoter Methylation and Expression of Inflammatory Genes IL-6 and TNF-α with the Risk of Coronary Artery Disease in Diabetic and Obese Subjects among Asian Indians.Indian journal of clinical biochemistry : IJCB · 2022Article
- Amino Acids and the Early Mammalian Embryo: Origin, Fate, Function and Life-Long Legacy.International journal of environmental research and public health · 2021Review
- A primer on metabolic memory: why existing diabesity treatments fail.Clinical kidney journal · 2021Review
- Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems.Epigenomics · 2020Article
- Neighborhoods to Nucleotides - Advances and gaps for an obesity disparities systems epidemiology model.Current epidemiology reports · 2019Article
- RANK/RANKL/OPG pathway is an important for the epigenetic regulation of obesity.Molecular biology reports · 2019Article
- Article
- Genome- and epigenome-wide association study of hypertriglyceridemic waist in Mexican American families.Clinical epigenetics · 2016Article
- Lack of Association betweenJournal of diabetes research · 2016Article
- Novel epigenetic determinants of type 2 diabetes in Mexican-American families.Human molecular genetics · 2015Article
- Differential DNA Methylation in Relation to Age and Health Risks of Obesity.International journal of molecular sciences · 2015Article
- Reversibility and heritability of liver fibrosis: Implications for research and therapy.World journal of gastroenterology · 2015Review
- Increased methylation of interleukin 6 gene is associated with obesity in Korean women.Molecules and cells · 2015Article
- The impact of genetic variation and cigarette smoke on DNA methylation in current and former smokers from the COPDGene study.Epigenetics · 2015Article
- An epigenetic map of age-associated autosomal loci in northern European families at high risk for the metabolic syndrome.Clinical epigenetics · 2015Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
Several studies have identified effects of genetic variation on DNA methylation patterns and associated heritability, with research primarily focused on Caucasian individuals. In this paper, we examine the evidence for genetic effects on DNA methylation in a Mexican American cohort, a population burdened by a high prevalence of obesity. Using an Illumina-based platform and following stringent quality control procedures, we assessed a total of 395 CpG sites in peripheral blood samples obtained from 183 Mexican American individuals for evidence of heritability, proximal genetic regulation and association with age, sex and obesity measures (i.e. waist circumference and body mass index). We identified 16 CpG sites (~4%) that were significantly heritable after Bonferroni correction for multiple testing and 27 CpG sites (~6.9%) that showed evidence of genetic effects. Six CpG sites (~2%) were associated with age, primarily exhibiting positive relationships, including CpG sites in two genes that have been implicated in previous genome-wide methylation studies of age (FZD9 and MYOD1). In addition, we identified significant associations between three CpG sites (~1%) and sex, including DNA methylation in CASP6, a gene that may respond to estradiol treatment, and in HSD17B12, which encodes a sex steroid hormone. Although we did not identify any significant associations between DNA methylation and the obesity measures, several nominally significant results were observed in genes related to adipogenesis, obesity, energy homeostasis and glucose homeostasis (ARHGAP9, CDKN2A, FRZB, HOXA5, JAK3, MEST, NPY, PEG3 and SMARCB1). In conclusion, we were able to replicate several findings from previous studies in our Mexican American cohort, supporting an important role for genetic effects on DNA methylation. In addition, we found a significant influence of age and sex on DNA methylation, and report on trend-level, novel associations between DNA methylation and measures of obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.