ArticlePloS one2013
Heteroplasmy in the mitochondrial genomes of human lice and ticks revealed by high throughput sequencing.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Multiple Introductions of the Asian Longhorned Tick (Ecology and evolution · 2025Article
- The mitochondrial genome of Bottapotamon fukienense (Brachiura: Potamidae) is fragmented into two chromosomes.BMC genomics · 2024Article
- Unparalleled mitochondrial heteroplasmy andCurrent research in insect science · 2022Article
- Comparative hologenomics of twoPeerJ · 2021Article
- Genetic variation and heteroplasmy of Varroa destructor inferred from ND4 mtDNA sequences.Parasitology research · 2020Article
- Investigating the genetic diversity and presence of forensically informative nucleotide sequences in Indian antelope (Antilope cervicapra) using multiple genes of the mitochondrial genome.Molecular biology reports · 2019Article
- Paternal leakage and mtDNA heteroplasmy in Rhipicephalus spp. ticks.Scientific reports · 2019Article
- The Complete Mitochondrial Genome and Expression Profile of Mitochondrial Protein-Coding Genes in the Bisexual and ParthenogeneticFrontiers in physiology · 2019Article
- Mitochondrial genomes of two diplectanids (Platyhelminthes: Monogenea) expose paraphyly of the order Dactylogyridea and extensive tRNA gene rearrangements.Parasites & vectors · 2018Article
- Haplotype identification and detection of mitochondrial DNA heteroplasmy in Varroa destructor mites using ARMS and PCR-RFLP methods.Experimental & applied acarology · 2016Article
- Article
- Fragmented mitochondrial genomes in two suborders of parasitic lice of eutherian mammals (Anoplura and Rhynchophthirina, Insecta).Scientific reports · 2015Article
- Comparative population genetics of two invading ticks: Evidence of the ecological mechanisms underlying tick range expansions.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2015Article
- Correction: Heteroplasmy in the mitochondrial genomes of human lice and ticks revealed by high throughput sequencing.PloS one · 2015Article
- Population and demographic structure of Ixodes scapularis Say in the eastern United States.PloS one · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The typical mitochondrial (mt) genomes of bilateral animals consist of 37 genes on a single circular chromosome. The mt genomes of the human body louse, Pediculus humanus, and the human head louse, Pediculus capitis, however, are extensively fragmented and contain 20 minichromosomes, with one to three genes on each minichromosome. Heteroplasmy, i.e. nucleotide polymorphisms in the mt genome within individuals, has been shown to be significantly higher in the mt cox1 gene of human lice than in humans and other animals that have the typical mt genomes. To understand whether the extent of heteroplasmy in human lice is associated with mt genome fragmentation, we sequenced the entire coding regions of all of the mt minichromosomes of six human body lice and six human head lice from Ethiopia, China and France with an Illumina HiSeq platform. For comparison, we also sequenced the entire coding regions of the mt genomes of seven species of ticks, which have the typical mitochondrial genome organization of bilateral animals. We found that the level of heteroplasmy varies significantly both among the human lice and among the ticks. The human lice from Ethiopia have significantly higher level of heteroplasmy than those from China and France (Pt<0.05). The tick, Amblyomma cajennense, has significantly higher level of heteroplasmy than other ticks (Pt<0.05). Our results indicate that heteroplasmy level can be substantially variable within a species and among closely related species, and does not appear to be determined by single factors such as genome fragmentation.
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