ArticlePloS one2013
Cardiac myocyte diversity and a fibroblast network in the junctional region of the zebrafish heart revealed by transmission and serial block-face scanning electron microscopy.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed.
- Article
- Primordial cardiomyocytes orchestrate myocardial morphogenesis and vascularization but are dispensable for regeneration.bioRxiv : the preprint server for biology · 2025Article
- The effect of non-local coupling of fibroblasts on pacing dynamics in a 2D tissue: a simulation study.Scientific reports · 2025Article
- Distinct features of the regenerating heart uncovered through comparative single-cell profiling.Biology open · 2024Article
- Article
- Modulation of VEGFA Signaling During Heart Regeneration in Zebrafish.Methods in molecular biology (Clifton, N.J.) · 2022Review
- Proteomic Analysis of Exosomes during Cardiogenic Differentiation of Human Pluripotent Stem Cells.Cells · 2021Article
- Exercise, programmed cell death and exhaustion of cardiomyocyte proliferation in aging zebrafish.Disease models & mechanisms · 2021Article
- Serial Block-Face Scanning Electron Microscopy (SBF-SEM) of Biological Tissue Samples.Journal of visualized experiments : JoVE · 2021Article
- Reactive oxygen species during heart regeneration in zebrafish: Lessons for future clinical therapies.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2021Review
- Cauterization as a Simple Method for Regeneration Studies in the Zebrafish Heart.Journal of cardiovascular development and disease · 2020Article
- Living myofibroblast-silicon composites for probing electrical coupling in cardiac systems.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Serial block-face scanning electron microscopy reveals neuronal-epithelial cell fusion in the mouse cornea.PloS one · 2019Article
- The epicardium as a hub for heart regeneration.Nature reviews. Cardiology · 2018Review
- Transient fibrosis resolves via fibroblast inactivation in the regenerating zebrafish heart.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The careg element reveals a common regulation of regeneration in the zebrafish myocardium and fin.Nature communications · 2017Article
- Deletion of Pr130 Interrupts Cardiac Development in Zebrafish.International journal of molecular sciences · 2016Article
- Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration.Science advances · 2016Article
- Differential Lectin Binding Patterns Identify Distinct Heart Regions in Giant Danio ( Devario aequipinnatus) and Zebrafish ( Danio rerio) Hearts.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2016Article
- Mouse myofibers lacking the SMYD1 methyltransferase are susceptible to atrophy, internalization of nuclei and myofibrillar disarray.Disease models & mechanisms · 2016Article
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Authors and funding
6 authors.
Funding
Abstract
The zebrafish has emerged as an important model of heart development and regeneration. While the structural characteristics of the developing and adult zebrafish ventricle have been previously studied, little attention has been paid to the nature of the interface between the compact and spongy myocardium. Here we describe how these two distinct layers are structurally and functionally integrated. We demonstrate by transmission electron microscopy that this interface is complex and composed primarily of a junctional region occupied by collagen, as well as a population of fibroblasts that form a highly complex network. We also describe a continuum of uniquely flattened transitional cardiac myocytes that form a circumferential plate upon which the radially-oriented luminal trabeculae are anchored. In addition, we have uncovered within the transitional ring a subpopulation of markedly electron dense cardiac myocytes. At discrete intervals the transitional cardiac myocytes form contact bridges across the junctional space that are stabilized through localized desmosomes and fascia adherentes junctions with adjacent compact cardiac myocytes. Finally using serial block-face scanning electron microscopy, segmentation and volume reconstruction, we confirm the three-dimensional nature of the junctional region as well as the presence of the sheet-like fibroblast network. These ultrastructural studies demonstrate the previously unrecognized complexity with which the compact and spongy layers are structurally integrated, and provide a new basis for understanding development and regeneration in the zebrafish heart.
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