ArticlePloS one2013
Network-level structural abnormalities of cerebral cortex in type 1 diabetes mellitus.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Acute hyperglycaemia leads to altered frontal lobe brain activity and reduced working memory in type 2 diabetes.PloS one · 2021Trial
- Brain network alterations in autoimmune diseases: Current status and future prospects.iScience · 2026Review
- Shared genetic and molecular architecture between insulin resistance and cognitive performance.medRxiv : the preprint server for health sciences · 2026Article
- Executive functioning-related neural processes in emerging adults with type 1 diabetes.Brain imaging and behavior · 2026Article
- Diabetic impact on the neuroaxis: from peripheral neuropathy to central neurodegeneration.Frontiers in endocrinology · 2026Review
- Acute brain responses to hypoglycaemia and hyperglycaemia in adolescents with type 1 diabetes.Diabetologia · 2025Observational
- Brain Structure Among Middle-aged and Older Adults With Long-standing Type 1 Diabetes in the DCCT/EDIC Study.Diabetes care · 2022Article
- Effect of verbal task complexity in a working memory paradigm in patients with type 1 diabetes. A fMRI study.PloS one · 2017Article
- Altered Integration of Structural Covariance Networks in Young Children With Type 1 Diabetes.Human brain mapping · 2016Article
- Disrupted subject-specific gray matter network properties and cognitive dysfunction in type 1 diabetes patients with and without proliferative retinopathy.Human brain mapping · 2016Article
- Positron Emission Tomography Reveals Abnormal Topological Organization in Functional Brain Network in Diabetic Patients.Frontiers in neuroscience · 2016Article
- Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity.Molecular metabolism · 2015Article
- Review
Corrections and comments
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Authors and funding
16 authors at 9 institutions in 2 countries.
Funding
Abstract
Type 1 diabetes mellitus (T1DM) usually begins in childhood and adolescence and causes lifelong damage to several major organs including the brain. Despite increasing evidence of T1DM-induced structural deficits in cortical regions implicated in higher cognitive and emotional functions, little is known whether and how the structural connectivity between these regions is altered in the T1DM brain. Using inter-regional covariance of cortical thickness measurements from high-resolution T1-weighted magnetic resonance data, we examined the topological organizations of cortical structural networks in 81 T1DM patients and 38 healthy subjects. We found a relative absence of hierarchically high-level hubs in the prefrontal lobe of T1DM patients, which suggests ineffective top-down control of the prefrontal cortex in T1DM. Furthermore, inter-network connections between the strategic/executive control system and systems subserving other cortical functions including language and mnemonic/emotional processing were also less integrated in T1DM patients than in healthy individuals. The current results provide structural evidence for T1DM-related dysfunctional cortical organization, which specifically underlie the top-down cognitive control of language, memory, and emotion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.