ArticleEvidence-based complementary and alternative medicine : eCAM2013
A network study of chinese medicine xuesaitong injection to elucidate a complex mode of action with multicompound, multitarget, and multipathway.
Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Exploring the mechanism of Panax notoginseng injection in the treatment of skin wound based on network pharmacology and experimental verification.Journal of molecular histology · 2026Article
- Article
- Network Pharmacology Approach for Medicinal Plants: Review and Assessment.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Integrated Network Pharmacology Analysis andMolecules (Basel, Switzerland) · 2021Article
- Study on the Sleep-Improvement Effects ofFoods (Basel, Switzerland) · 2021Article
- An ultra-robust fingerprinting method for quality assessment of traditional Chinese medicine using multiple reaction monitoring mass spectrometry.Journal of pharmaceutical analysis · 2021Article
- Underlying Mechanism and Active Ingredients of Tianma Gouteng Acting on Cerebral Infarction as DeterminedFrontiers in pharmacology · 2021Article
- A Bioassay-Based Approach for the Batch-To-Batch Consistency Evaluation of Xuesaitong Injection on a Zebrafish Thrombosis Model.Frontiers in pharmacology · 2021Article
- New dammarane-type triterpenoid saponins fromJournal of ginseng research · 2020Article
- Critical pharmaceutical process identification considering chemical composition, biological activity, and batch-to-batch consistency: A case study of notoginseng total saponins.Chinese herbal medicines · 2020Article
- HLA-C*12:02 is strongly associated with Xuesaitong-induced cutaneous adverse drug reactions.The pharmacogenomics journal · 2019Article
- Identification of Steroidogenic Components Derived FromFrontiers in pharmacology · 2018Article
- Endophytic fungi harbored inJournal of ginseng research · 2017Article
- A Bioactive Chemical Markers Based Strategy for Quality Assessment of Botanical Drugs: Xuesaitong Injection as a Case Study.Scientific reports · 2017Article
- Combining Chemical Profiling and Network Analysis to Investigate the Pharmacology of Complex Prescriptions in Traditional Chinese Medicine.Scientific reports · 2017Article
- Endothelium-dependent vasodilation effects ofExperimental and therapeutic medicine · 2016Article
- Cardiovascular Disease Chemogenomics Knowledgebase-guided Target Identification and Drug Synergy Mechanism Study of an Herbal Formula.Scientific reports · 2016Article
- Bioinformatics investigation of therapeutic mechanisms of Xuesaitong capsule treating ischemic cerebrovascular rat model with comparative transcriptome analysis.American journal of translational research · 2016Article
- Evaluating the antidiabetic effects of Chinese herbal medicine: Xiao-Ke-An in 3T3-L1 cells and KKAy mice using both conventional and holistic omics approaches.BMC complementary and alternative medicine · 2015Article
- Deciphering the therapeutic mechanisms of Xiao-Ke-An in treatment of type 2 diabetes in mice by a Fangjiomics approach.Acta pharmacologica Sinica · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chinese medicine has evolved from thousands of years of empirical applications and experiences of combating diseases. It has become widely recognized that the Chinese medicine acts through complex mechanisms featured as multicompound, multitarget and multipathway. However, there is still a lack of systematic experimental studies to elucidate the mechanisms of Chinese medicine. In this study, the differentially expressed genes (DEGs) were identified from myocardial infarction rat model treated with Xuesaitong Injection (XST), a Chinese medicine consisting of the total saponins from Panax notoginseng (Burk.) F. H. Chen (Chinese Sanqi). A network-based approach was developed to combine DEGs related to cardiovascular diseases (CVD) with lines of evidence from the literature mining to investigate the mechanism of action (MOA) of XST on antimyocardial infarction. A compound-target-pathway network of XST was constructed by connecting compounds to DEGs validated with literature lines of evidence and the pathways that are functionally enriched. Seventy potential targets of XST were identified in this study, of which 32 were experimentally validated either by our in vitro assays or by CVD-related literatures. This study provided for the first time a network view on the complex MOA of antimyocardial infarction through multiple targets and pathways.
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Registered trials
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