ArticleEvidence-based complementary and alternative medicine : eCAM2013
Hepatoprotective Effect of Fermented Soybean (Nutrient Enriched Soybean Tempeh) against Alcohol-Induced Liver Damage in Mice.
Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 47 citations in OpenAlex.
- Effect of fermented soybean meal supplementation and birth weight of broiler on performance, hematochemical parameters, and lactic acid bacteria composition under tropical conditions.Poultry science · 2026Article
- In vivo toxicity and antioxidant of pressurize hot water Phyllanthus tenellus Roxb. extracts.BMC complementary medicine and therapies · 2021Article
- The fermented soy beverage Q-CAN® plus induces beneficial changes in the oral and intestinal microbiome.BMC nutrition · 2021Article
- Black soybean tempeh and purple sweet potato improve sperm quality in streptozotocin-induced diabetic rats.Veterinary world · 2020Article
- Protective effects of synbiotic soymilk fortified with whey protein concentrate and zinc sulfate against bile duct ligated-induced hepatic encephalopathy.Gastroenterology and hepatology from bed to bench · 2020Article
- Anti-inflammatory, analgesic and acute toxicity effects of fermented soybean.BMC complementary and alternative medicine · 2019Article
- Soy products fermented with sprouted garlic have increased neuroprotective activities and restore cognitive functions.Food science and biotechnology · 2016Article
- Anti-inflammatory and antioxidant effects of umbelliferone in chronic alcohol-fed rats.Nutrition research and practice · 2015Article
- Antioxidant effects of pineapple vinegar in reversing of paracetamol-induced liver damage in mice.Chinese medicine · 2015Article
- AP-1-Targeting Anti-Inflammatory Activity of the Methanolic Extract of Persicaria chinensis.Evidence-based complementary and alternative medicine : eCAM · 2015Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, soybean tempeh has received great attention due to many advantages such as higher nutritional value, lower production cost, and shorter fermentation time. In this study, the in vivo hepatoprotective and antioxidant effects of nutrient enriched soybean tempeh (NESTE) were determined. NESTE fermentation process which involved anaerobic incubation was previously proclaimed to increase the content of amino acids and antioxidant properties remarkably. The evaluation of histological sections, serum biochemical markers (aspartate aminotransferase (AST), alanine aminotransferase (ALT), and cholesterol and triglycerides (TG)), liver immune response level (nitric oxide (NO)) and liver antioxidant level (superoxide dismutase (SOD), ferric reducing antioxidant power (FRAP), and malondialdehyde (MDA)) was conducted in order to compare the effects of nonfermented soybean extract (SBE) and fermented soybean extract (NESTE) on alcohol-induced liver damage in mice. Results demonstrated that 1000 mg/kg of NESTE can significantly reduce the levels of AST, ALT, cholesterol, TG, MDA, and NO. On the other hand, it also raised the level of SOD and FRAP. Furthermore, the histological examination on 1000 mg/kg NESTE treatment group showed that this extract was capable of recovering the damaged hepatocytes to their normal structures. Thus, it can be concluded that NESTE produced through fermentation process was able to enhance hepatoprotective and antioxidant effects in vivo.
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Registered trials
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