ReviewFrontiers in genetics2013
(Epi)genetics of pregnancy-associated diseases.
Review in Frontiers in genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Aberrant Uteroplacental and Vascular Signaling and Remodeling by Matrix Metalloproteinases in Pregnancy-Related Hypertension and Preeclampsia.Biomolecules · 2026Review
- KCNK2-mediated regulation of MMP-2/9 by PlGF influences uterine artery function in pregnancy-induced hypertension.BMC pregnancy and childbirth · 2025Article
- Long non-coding RNA myocardial infarction associated transcript expression and clinical significance in patients with hypertension during pregnancy.Irish journal of medical science · 2022Article
- Article
- Mesenchymal stem cells-derived exosomes improve pregnancy outcome through inducing maternal tolerance to the allogeneic fetus in abortion-prone mating mouse.The Kaohsiung journal of medical sciences · 2020Article
- Disordered p53-MALAT1 pathway is associated with recurrent miscarriage.The Kaohsiung journal of medical sciences · 2019Article
- Downregulated MALAT1 relates to recurrent pregnancy loss via sponging miRNAs.The Kaohsiung journal of medical sciences · 2018Article
- Hemochorial placentation: development, function, and adaptations.Biology of reproduction · 2018Review
- Integrated Systems Biology Approach Identifies Novel Maternal and Placental Pathways of Preeclampsia.Frontiers in immunology · 2018Article
- Grandmaternal stress during pregnancy and DNA methylation of the third generation: an epigenome-wide association study.Translational psychiatry · 2017Article
- Matrix Metalloproteinases in Normal Pregnancy and Preeclampsia.Progress in molecular biology and translational science · 2017Review
- Mechanisms of Endothelial Dysfunction in Hypertensive Pregnancy and Preeclampsia.Advances in pharmacology (San Diego, Calif.) · 2016Article
- Bioactive factors in uteroplacental and systemic circulation link placental ischemia to generalized vascular dysfunction in hypertensive pregnancy and preeclampsia.Biochemical pharmacology · 2015Review
- ANP-induced signaling cascade and its implications in renal pathophysiology.American journal of physiology. Renal physiology · 2015Review
- Article
- Transcriptome interrogation of human myometrium identifies differentially expressed sense-antisense pairs of protein-coding and long non-coding RNA genes in spontaneous labor at term.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2014Article
- Pregnancy, parturition and preeclampsia in women of African ancestry.American journal of obstetrics and gynecology · 2014Review
- Adaptive mechanisms controlling uterine spiral artery remodeling during the establishment of pregnancy.The International journal of developmental biology · 2014Review
- Natural killer cells and regulatory T cells in early pregnancy loss.The International journal of developmental biology · 2014Review
- (Epi)genetic control of human trophoblast invasion.Frontiers in genetics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review describes the current knowledge regarding genetics and epigenetics of pregnancy-associated diseases with placental origin. We discuss the effect on genetic linkage analyses when the fetal genotype determines the maternal phenotype. Secondly, the genes identified by genome-wide linkage studies to be associated with pre-eclampsia (ACVR2A, STOX1) and the HELLP-syndrome (LINC-HELLP) are discussed regarding their potential functions in the etiology of disease. Furthermore, susceptibility genes identified by candidate gene approaches (e.g., CORIN) are described. Next, we focus on the additional challenges that come when epigenetics also play a role in disease inheritance. We discuss the maternal transmission of the chromosome 10q22 pre-eclampsia linkage region containing the STOX1 gene and provide further evidence for the role of epigenetics in pre-eclampsia based on the cdkn1c mouse model of pre-eclampsia. Finally, we provide recommendations to unravel the genetics of pregnancy-associated diseases, specifically regarding clear definitions of patient groups and sufficient patient numbers, and the potential usefulness of (epi)genetic data in early non-invasive biomarker development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.