ArticleFrontiers in behavioral neuroscience2013
Neudesin is involved in anxiety behavior: structural and neurochemical correlates.
Article in Frontiers in behavioral neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
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- Shared and unique transcriptomic signatures of antidepressant and probiotics action in the mammalian brain.Molecular psychiatry · 2024Article
- Identification of the tumor metastasis-related tumor subgroups overexpressed NENF in triple-negative breast cancer by single-cell transcriptomics.Cancer cell international · 2024Article
- Cerebrospinal fluid proteomic signatures are associated with symptom severity of first-episode psychosis.Journal of psychiatric research · 2024Article
- A secretory protein neudesin regulates splenic red pulp macrophages in erythrophagocytosis and iron recycling.Communications biology · 2024Article
- Genome-wide transcriptomics of the amygdala reveals similar oligodendrocyte-related responses to acute and chronic alcohol drinking in female mice.Translational psychiatry · 2022Article
- Can the administration of platelet lysates to the brain help treat neurological disorders?Cellular and molecular life sciences : CMLS · 2022Review
- Imperatorin Influences Depressive-like Behaviors: A Preclinical Study on Behavioral and Neurochemical Sex Differences.Molecules (Basel, Switzerland) · 2022Article
- Effect of Neudesin Neurotrophic Factor on Differentiation of Bovine Preadipocytes and Myoblasts in a Co-Culture System.Animals : an open access journal from MDPI · 2020Article
- Neudesin in obesity and type 2 diabetes mellitus: the effect of acute fasting and weight reducing interventions.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Adult Hippocampal Neurogenesis Modulation by the Membrane-Associated Progesterone Receptor Family Member Neudesin.Frontiers in cellular neuroscience · 2018Article
- Effect of Levodopa on Reward and Impulsivity in a Rat Model of Parkinson's Disease.Frontiers in behavioral neuroscience · 2017Article
- Tau protein is essential for stress-induced brain pathology.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Deletion of the Neurotrophic Factor neudesin Prevents Diet-induced Obesity by Increased Sympathetic Activity.Scientific reports · 2015Article
- Neudesin as a unique secreted protein with multi-functional roles in neural functions, energy metabolism, and tumorigenesis.Frontiers in molecular biosciences · 2015Review
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neudesin (also known as neuron derived neurotrophic factor, Nenf) is a scarcely studied putative non-canonical neurotrophic factor. In order to understand its function in the brain, we performed an extensive behavioral characterization (motor, emotional, and cognitive dimensions) of neudesin-null mice. The absence of neudesin leads to an anxious-like behavior as assessed in the elevated plus maze (EPM), light/dark box (LDB) and novelty suppressed feeding (NSF) tests, but not in the acoustic startle (AS) test. This anxious phenotype is associated with reduced dopaminergic input and impoverished dendritic arborizations in the dentate gyrus granule neurons of the ventral hippocampus. Interestingly, shorter dendrites are also observed in the bed nucleus of the stria terminalis (BNST) of neudesin-null mice. These findings lead us to suggest that neudesin is a novel relevant player in the maintenance of the anxiety circuitry.
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