ArticlePolymer2013
Quantitative analysis of generation and branch defects in G5 poly(amidoamine) dendrimer.
Article in Polymer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Preparation of gastrodin-modified dendrimer-entrapped gold nanoparticles as a drug delivery system for cerebral ischemia-reperfusion injury.Brain and behavior · 2022Article
- Article
- Spatially Controlled Highly Branched Vinylsilicones.Polymers · 2021Article
- Distributions: The Importance of the Chemist's Molecular View for Biological Materials.Biomacromolecules · 2018Review
- Function Oriented Molecular Design: Dendrimers as Novel Antimicrobials.Molecules (Basel, Switzerland) · 2017Review
- Increase in Dye:Dendrimer Ratio Decreases Cellular Uptake of Neutral Dendrimers in RAW Cells.ACS biomaterials science & engineering · 2016Article
- Characterization of Polyamidoamino (PAMAM) Dendrimers Using In-Line Reversed Phase LC Electrospray Ionization Mass Spectrometry.Analytical methods : advancing methods and applications · 2016Article
- Rapid Exchange Between Free and Bound States in RNA-Dendrimer Polyplexes: Implications on the Mechanism of Delivery and Release.Biomacromolecules · 2016Article
- Generation 3 PAMAM dendrimer TAMRA conjugates containing precise dye/dendrimer ratios.Materials today (Kidlington, England) · 2015Article
- Fluorophore:dendrimer ratio impacts cellular uptake and intracellular fluorescence lifetime.Bioconjugate chemistry · 2015Article
- Tweaking dendrimers and dendritic nanoparticles for controlled nano-bio interactions: potential nanocarriers for improved cancer targeting.Journal of drug targeting · 2015Review
- Poly(amidoamine) dendrimer-methotrexate conjugates: the mechanism of interaction with folate binding protein.Molecular pharmaceutics · 2014Article
- Multivalent polymers for drug delivery and imaging: the challenges of conjugation.Biomacromolecules · 2014Review
- Cationic PAMAM dendrimers as pore-blocking binary toxin inhibitors.Biomacromolecules · 2014Article
- Diffusion NMR study of generation-five PAMAM dendrimer materials.The journal of physical chemistry. B · 2014Article
- Avidity mechanism of dendrimer-folic acid conjugates.Molecular pharmaceutics · 2014Article
- Isolation and characterization of precise dye/dendrimer ratios.Chemistry (Weinheim an der Bergstrasse, Germany) · 2014Article
- PAMAM Dendrimers as Quantized Building Blocks for Novel Nanostructures.Soft matter · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Although methods have been developed to synthesize and isolate generation 5 (G5) PAMAM dendrimers containing precise numbers of ligands per polymer particle, the presence of skeletal and generational defects in this material can substantially hamper the process. Here we provide a quantitative analysis of G5 PAMAM dendrimer defects via high performance liquid chromatography, potentiometric titration, mass spectrometry, size exclusion chromatography, and nuclear magnetic resonance. We identified, isolated, and characterized the major structural defects of G5 dendrimer, trailing generations, and dimer, trimer, and tetramer species. We determine that the G5 material present in the as-received mixture contains 93 arms on average. We have developed two model systems capable of generating the experimentally observed mass range and polydispersity at defect rates of 8-15%.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.