ArticlePlant & cell physiology2013
Nitrogen-dependent regulation of de novo cytokinin biosynthesis in rice: the role of glutamine metabolism as an additional signal.
Article in Plant & cell physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 129 citations in OpenAlex.
- Physiological and Molecular Mechanisms of Nitrogen Regulation on Grain Quality in Cereal Crops at Later Stages.International journal of molecular sciences · 2026Review
- Local adjustment of exodermis to nutrient deficiency in crop species.Frontiers in plant science · 2026Article
- Innovative metabolic reprogramming in rice: unlocking drought resilience through microbial consortia interaction and sustainable agriculture.3 Biotech · 2025Review
- Exploring the Cytokinin Profile ofMetabolites · 2025Article
- The Research Progress on the Effects of Phytohormones on Nitrogen Use Efficiency in Rice.Plants (Basel, Switzerland) · 2025Review
- Five unaddressed questions about cytokinin biosynthesis.Journal of experimental botany · 2025Review
- Spatially distributed cytokinins: Metabolism, signaling, and transport.Plant communications · 2024Review
- Unlocking the Multifaceted Mechanisms of Bud Outgrowth: Advances in Understanding Shoot Branching.Plants (Basel, Switzerland) · 2023Review
- Transcriptomic analysis implicates ABA signaling and carbon supply in the differential outgrowth of petunia axillary buds.BMC plant biology · 2023Article
- A cell wall-localized cytokinin/purine riboside nucleosidase is involved in apoplastic cytokinin metabolism inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- The trans-zeatin-type side-chain modification of cytokinins controls rice growth.Plant physiology · 2023Article
- Plant nitrogen availability and crosstalk with phytohormones signallings and their biotechnology breeding application in crops.Plant biotechnology journal · 2023Review
- A developed system to extract specific responses of increment length in rice shoots under gradient changes in nitrogen concentration regimes.Plant biotechnology (Tokyo, Japan) · 2023Article
- Nutrition regulates sex expression in a gender diphasy plant,Frontiers in plant science · 2023Article
- The source, level, and balance of nitrogen during the somatic embryogenesis process drive cellular differentiation.Planta · 2022Review
- Coal fly ash and nitrogen application as eco-friendly approaches for modulating the growth, yield, and biochemical constituents of radish plants.Saudi journal of biological sciences · 2022Article
- Nitrogen represses haustoria formation through abscisic acid in the parasitic plant Phtheirospermum japonicum.Nature communications · 2022Article
- Regulation of ammonium acquisition and use in Oryza longistaminata ramets under nitrogen source heterogeneity.Plant physiology · 2022Article
- Nitrogen application and differences in leaf number retained after topping affect the tobacco (Nicotiana tabacum) transcriptome and metabolome.BMC plant biology · 2022Article
- A high trans-zeatin nucleoside concentration in corms may promote the multileaf growth ofFrontiers in plant science · 2022Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytokinin activity in plants is closely related to nitrogen availability, and an Arabidopsis gene for adenosine phosphate-isopentenyltransferase (IPT), IPT3, is regulated by inorganic nitrogen sources in a nitrate-specific manner. In this study, we have identified another regulatory system of cytokinin de novo biosynthesis in response to nitrogen status. In rice, OsIPT4, OsIPT5, OsIPT7 and OsIPT8 were up-regulated in response to exogenously applied nitrate and ammonium, with accompanying accumulation of cytokinins. Pre-treatment of roots with l-methionine sulfoximine, a potent inhibitor of glutamine synthetase, abolished the nitrate- and ammonium-dependent induction of OsIPT4 and OsIPT5, while glutamine application induced their expression. Thus, neither nitrate nor ammonium, but glutamine or a related metabolite, is essential for the induction of these IPT genes in rice. On the other hand, glutamine-dependent induction of IPT3 occurs in Arabidopsis, at least to some extent. In transgenic lines repressing the expression of OsIPT4, which is the dominant IPT in rice roots, the nitrogen-dependent increase of cytokinin in the xylem sap was significantly reduced, and seedling shoot growth was retarded despite sufficient nitrogen. We conclude that plants possess multiple regulation systems for nitrogen-dependent cytokinin biosynthesis to modulate growth in response to nitrogen availability.
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