ArticleInvestigative ophthalmology & visual science2013
The TFOS International Workshop on Contact Lens Discomfort: report of the subcommittee on neurobiology.
Article in Investigative ophthalmology & visual science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05745220 (Corneal Sensitivity in Silicone Hydrogel Contact Lens Wear), which is not on this map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Corneal Sensitivity in Silicone Hydrogel Contact Lens Wear
Who cites it
39 citing papers in PubMed, 98 citations in OpenAlex.
- Effect of Three Interventions on Contact Lens Comfort in Symptomatic Wearers: A Randomized Clinical Trial.PloS one · 2015Trial
- Recent Advances in Extended Ocular Drug Delivery for the Ocular Surface.Molecules (Basel, Switzerland) · 2026Review
- Validation and Comparative Analysis of a Contemporary Non-Contact Corneal Aesthesiometer.Journal of clinical medicine · 2026Article
- Comfort and Ocular Surface Impact of Verofilcon A Daily Disposable Contact Lenses in Satisfied Senofilcon A Daily Disposable Lens Wearers: A Prospective Non-Interventional Study [Letter].Clinical optometry · 2026Article
- Tear aqueous production rate between symptomatic and asymptomatic soft contact lens wearers.Optometry and vision science : official publication of the American Academy of Optometry · 2025Article
- The Influence of Lid-Parallel Conjunctival Folds and Conjunctivochalasis on Dry Eye Symptoms with and Without Contact Lens Wear: A Review of the Literature.Ophthalmology and therapy · 2024Review
- Hydrogel dressings on neurotrophic keratitis in an experimental animal model.International journal of ophthalmology · 2024Article
- Functional Changes of the Ocular Surface Sensory Nerves Due to Contact Lens Use in Young Symptomatic and Asymptomatic Users.Investigative ophthalmology & visual science · 2023Article
- Smartphone gaming induces dry eye symptoms and reduces blinking in school-aged children.Eye (London, England) · 2023Article
- Evaluation of corneal dendritic cell density and subbasal nerve density in contact lens wearers using IVCM: A systematic review and meta-analysis.Frontiers in medicine · 2023Review
- Evaluation of Corneal Alterations After Short-Term Silicone Hydrogel Contact Lens Use by Confocal Microscopy.Turkish journal of ophthalmology · 2022Article
- Ocular Surface Immune Cell Profiles in Contact Lens-Induced Discomfort.Translational vision science & technology · 2022Article
- Working principle and relevant physical properties of the Swiss Liquid Jet Aesthesiometer for Corneal Sensitivity (SLACS) evaluation.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2022Article
- Immunity and pain in the eye: focus on the ocular surface.Clinical and experimental immunology · 2022Review
- Dynamic Changes of Ocular Surface in First-Time Contact Lens Wearers and the Effective Factors of Contact Lens Discomfort.Frontiers in medicine · 2022Article
- The Human Tissue-Engineered Cornea (hTEC): Recent Progress.International journal of molecular sciences · 2021Review
- Impact of Attrition, Intercellular Shear in Dry Eye Disease: When Cells are Challenged and Neurons are Triggered.International journal of molecular sciences · 2020Review
- Role of TRPM8 Channels in Altered Cold Sensitivity of Corneal Primary Sensory Neurons Induced by Axonal Damage.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Efficacy of autologous serum tears for treatment of neuropathic corneal pain.The ocular surface · 2019Article
- Corneal pain and experimental model development.Progress in retinal and eye research · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 8 institutions in 3 countries.
Funding
Abstract
This report characterizes the neurobiology of the ocular surface and highlights relevant mechanisms that may underpin contact lens-related discomfort. While there is limited evidence for the mechanisms involved in contact lens-related discomfort, neurobiological mechanisms in dry eye disease, the inflammatory pathway, the effect of hyperosmolarity on ocular surface nociceptors, and subsequent sensory processing of ocular pain and discomfort have been at least partly elucidated and are presented herein to provide insight in this new arena. The stimulus to the ocular surface from a contact lens is likely to be complex and multifactorial, including components of osmolarity, solution effects, desiccation, thermal effects, inflammation, friction, and mechanical stimulation. Sensory input will arise from stimulation of the lid margin, palpebral and bulbar conjunctiva, and the cornea.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.